Mohanty Partha Sarathi, Naaz Farah, Bansal Avi Kumar, Gupta Umesh Datta
Microbiology and Molecular Biology National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Medical Division National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Mol Biol Res Commun. 2017 Sep;6(3):113-122. doi: 10.22099/mbrc.2017.4084.
The emergence of drug resistance in leprosy is a major hurdle in leprosy elimination programme. Although the problem of drug resistance is presently not acute, it is important that we collect data more systematically and monitor the trend carefully so that effective measures to combat this problem can be developed. The present study aimed at the explication of cross resistance of rifabutin and rifapentine to rifampicin which would be helpful to programme managers for implementing rifabutin or rifapentine in replace of rifampicin. In this study we built 3D model of the rpoB using Swiss Model and the modelled structure was docked with rifampicin, rifabutin and rifapentine. We established that these 3 antibiotics interact with the same binding region in the modelled rpoB of Thus we conclude that vocation of rifabutin and rifapentine could not be suitable in replace of rifampicin to combat with drug resistance leprosy.
麻风病耐药性的出现是麻风病消除计划中的一个主要障碍。尽管目前耐药问题并不严重，但重要的是我们要更系统地收集数据并仔细监测趋势，以便制定有效的措施来应对这个问题。本研究旨在阐明利福布汀和利福喷汀对利福平的交叉耐药性，这将有助于项目管理人员实施用利福布汀或利福喷汀替代利福平的方案。在本研究中，我们使用瑞士模型构建了rpoB的三维模型，并将建模结构与利福平、利福布汀和利福喷汀进行对接。我们确定这三种抗生素与建模的rpoB中的相同结合区域相互作用。因此，我们得出结论，利福布汀和利福喷汀不能替代利福平用于对抗耐药性麻风病。
