Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi", Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy.
Dipartimento di Medicina Sperimentale, Sezione di Sezione di Biotecnologie, Istologia Medica e Biologia Molecolare, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy.
Stem Cells Transl Med. 2017 Dec;6(12):2115-2125. doi: 10.1002/sctm.17-0138. Epub 2017 Oct 26.
Tumors are composed of different types of cancer cells that contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an important role in cancer initiation and progression. Like their stem cells counterpart, CSCs are also characterized by self-renewal and the capacity to differentiate. A particular population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into cells of mesodermal characteristics. Several studies have reported the potential pro-or anti-tumorigenic influence of MSCs on tumor initiation and progression. In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis. In other cases, resident or migrating MSCs can favor tumor angiogenesis and increase tumor aggressiveness. This interplay between MSCs and cancer cells is fundamental for cancerogenesis, progression, and metastasis. Therefore, an interesting topic is the relationship between cancer cells, CSCs, and MSCs, since contrasting reports about their respective influences have been reported. In this review, we discuss recent findings related to conflicting results on the influence of normal and CSCs in cancer development. The understanding of the role of MSCs in cancer is also important in cancer management. Stem Cells Translational Medicine 2017;6:2115-2125.
肿瘤由不同类型的癌细胞组成，这些癌细胞促进了肿瘤异质性的产生。在这些细胞群体中，癌症干细胞（CSC）在癌症的发生和发展中起着重要作用。与它们的干细胞对应物一样，CSC 也具有自我更新和分化的能力。CSC 的一个特定群体是间充质干细胞（MSC），它可以分化为中胚层特征的细胞。有几项研究报告了 MSC 对肿瘤起始和进展的潜在促肿瘤或抑肿瘤作用。事实上，MSC 被募集到伤口愈合部位，以修复受损组织，这一事件也与肿瘤发生有关。在其他情况下，常驻或迁移的 MSC 可以促进肿瘤血管生成并增加肿瘤的侵袭性。MSC 与癌细胞之间的这种相互作用对于癌症发生、进展和转移至关重要。因此，一个有趣的话题是癌细胞、CSC 和 MSC 之间的关系，因为关于它们各自影响的报告存在矛盾。在这篇综述中，我们讨论了与正常和 CSC 在癌症发展中的影响相关的有争议的结果的最新发现。了解 MSC 在癌症中的作用对于癌症的治疗也很重要。《干细胞转化医学》2017 年；6:2115-2125。
