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肾移植后的严重可避免事件及医院获得性疾病

Never events and hospital-acquired conditions after kidney transplant.

作者信息

Moghadamyeghaneh Zhobin, Chen Linda J, Alameddine Mahmoud, Gupta Anupam K, Burke George W, Ciancio Gaetano

机构信息

Department of Surgery, Division of Transplant Surgery, Jackson Memorial Hospital/University of Miami, Miami, FL, United States.

出版信息

Can Urol Assoc J. 2017 Nov;11(11):E431-E436. doi: 10.5489/cuaj.4370.

Abstract

INTRODUCTION

Never events (NE) and hospital-acquired conditions (HAC) after surgery have been designated as quality metrics in health-care by the Centres for Medicare and Medicaid Services (CMS).

METHODS

The Nationwide Inpatient Sample (NIS) database 2002-2012 was used to identify patientswho underwent kidney transplant. Multivariate analysis using logistic regression was used to identify outcomes and risk factors of HAC and NE after transplantation; however, we were limited by using a retrospective database missing some important variables specified for the kidney transplant, such as some operative factors, donor factors, and cold and warm ischemia times.

RESULTS

Among 35 058 patients who underwent kidney transplant, there were 11 NEs, all of which were due to retained foreign bodies. Among HAC after surgery, falling was the most common (44.9%), followed by poor glycemic control (21.7%), vascular catheter-associated infection (21%), and catheter-associated urinary tract infection (8%). HAC and NE after surgery lead to a significant increase in mortality (adjusted odds ratio [AOR] 2.49; p=0.04), hospitalization length (13 vs. 7 days; p<0.01), and total hospital charges ($231 801 vs. $146 717; p<0.01). A significantly higher risk of HAC or NE was seen for patients who had more loss of function before surgey (AOR 3.25; p<0.01) and patients expected to have higher postoperative mortality before operation (AOR 1.62; p=0.03).

CONCLUSIONS

Despite the limitations of the study, we found HAC and NE significantly increase mortality, hospitalization length, and total hospital charges of kidney transplant patients. Quality improvement initiatives should target HAC and NE in order to successfully reduce or prevent these events.

摘要

引言

手术相关的严重可避免事件(NE)和医院获得性疾病(HAC)已被美国医疗保险和医疗补助服务中心(CMS)指定为医疗保健领域的质量指标。

方法

使用2002 - 2012年全国住院患者样本(NIS)数据库来识别接受肾移植的患者。采用逻辑回归进行多变量分析,以确定移植后HAC和NE的结局及危险因素;然而,我们受限于使用的回顾性数据库缺少一些针对肾移植指定的重要变量,如一些手术因素、供体因素以及冷、热缺血时间。

结果

在35058例接受肾移植的患者中,有11例严重可避免事件,均为异物残留所致。术后医院获得性疾病中,跌倒最为常见(44.9%),其次是血糖控制不佳(21.7%)、血管导管相关感染(21%)和导尿管相关尿路感染(8%)。术后HAC和NE导致死亡率显著增加(校正比值比[AOR] 2.49;p = 0.04)、住院时间延长(13天对7天;p < 0.01)以及总住院费用增加(231801美元对146717美元;p < 0.01)。术前功能丧失更多的患者(AOR 3.25;p < 0.01)以及术前预计术后死亡率较高的患者(AOR 1.62;p = 0.03)发生HAC或NE的风险显著更高。

结论

尽管本研究存在局限性,但我们发现HAC和NE显著增加了肾移植患者的死亡率、住院时间和总住院费用。质量改进措施应以HAC和NE为目标,以便成功减少或预防这些事件。

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