多巴胺受体激动剂（RDS-127）的抗毒蕈碱活性可区分豚鼠心脏、回肠和气管中的M2毒蕈碱受体。
The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig.
作者信息
Sahin I, Ilhan M
机构信息
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey.
出版信息
Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:163-72.
The antimuscarinic action of a dopamine receptor agonist, 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) was evaluated using guinea-pig isolated electrically paced left atria, spontaneously beating atria, ileal longitudinal muscle and tracheal strip. RDS-127 competitively antagonized the responses to carbachol in all these tissues. RDS-127 exhibits higher selectivity for tracheal M2-muscarinic receptors than for cardiac and ileal receptors. In addition, the affinity of RDS-127 towards cardiac M2-muscarinic receptors was also greater than towards ileum. RDS-127 did not show any selectivity for M2-muscarinic receptors mediating negative inotropic and chronotropic effects.
使用豚鼠离体电刺激起搏左心房、自主搏动心房、回肠纵肌和气管条，评估了多巴胺受体激动剂2-二正丙基氨基-4,7-二甲氧基茚满（RDS-127）的抗毒蕈碱作用。RDS-127在所有这些组织中竞争性拮抗对卡巴胆碱的反应。RDS-127对气管M2-毒蕈碱受体的选择性高于对心脏和回肠受体的选择性。此外，RDS-127对心脏M2-毒蕈碱受体的亲和力也大于对回肠的亲和力。RDS-127对介导负性变力和变时作用的M2-毒蕈碱受体未表现出任何选择性。
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