Burdach S, Levitt L
Abteilung für Pädiatrische Hämatologie/Onkologie, Medizinische Einrichtungen der Universität Düsseldorf, W. Germany.
Behring Inst Mitt. 1988 Aug(83):56-67.
Studies are reviewed, which establish a novel regulatory role for the T cell surface molecule CD2 and the T cell lymphokine IL-2: Immunoregulation of hematopoiesis. IL-2 induces a receptor-specific inhibition of early erythroid progenitors. IL-2-induced inhibition of erythropoiesis is mediated by interferon-gamma protein release and is associated with interferon-gamma mRNA accumulation. CD3-triggered p55 IL-2 receptor expression is a prerequisite for IL-2-induced erythropoietic inhibition and is associated with p55 mRNA synthesis. Hematopoietic effects of IL-2 are mediated by CD2/LFA-3 receptor ligand interactions. The studies demonstrate that the regulatory roles of IL-2 and CD2 extend beyond governance of the immune system itself and can subserve to control red cell production in vitro.
对多项研究进行了综述，这些研究确立了T细胞表面分子CD2和T细胞淋巴因子IL-2的一种新的调节作用：造血的免疫调节。IL-2诱导对早期红系祖细胞的受体特异性抑制。IL-2诱导的红细胞生成抑制由γ干扰素蛋白释放介导，并与γ干扰素mRNA积累相关。CD3触发的p55 IL-2受体表达是IL-2诱导红细胞生成抑制的先决条件，并与p55 mRNA合成相关。IL-2的造血作用由CD2/LFA-3受体配体相互作用介导。这些研究表明，IL-2和CD2的调节作用不仅限于免疫系统自身的调控，还可在体外用于控制红细胞生成。
