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2
Treatment of lithium intoxication: facing the need for evidence.锂中毒的治疗：面对证据的需求。
Int J Bipolar Disord. 2015 Dec;3(1):23. doi: 10.1186/s40345-015-0040-2. Epub 2015 Oct 22.
3
Lithium treatment in elderly patients affected by mood disorders.
Riv Psichiatr. 2014 Jul-Aug;49(4):180-2. doi: 10.1708/1600.17456.
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Lithium: a review of pharmacology, clinical uses, and toxicity.锂：药理学、临床应用及毒性综述。
Eur J Pharmacol. 2014 Oct 5;740:464-73. doi: 10.1016/j.ejphar.2014.06.042. Epub 2014 Jun 30.
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QTc prolongation, torsades de pointes, and psychotropic medications.QTc 延长、尖端扭转型室性心动过速和精神类药物。
Psychosomatics. 2013 Jan-Feb;54(1):1-13. doi: 10.1016/j.psym.2012.11.001.
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The effects of lithium on renal function in older adults--a systematic review.锂对老年人肾功能的影响——系统评价。
J Geriatr Psychiatry Neurol. 2012 Mar;25(1):51-61. doi: 10.1177/0891988712436690.
7
The science and practice of lithium therapy.锂疗法的科学与实践。
Aust N Z J Psychiatry. 2012 Mar;46(3):192-211. doi: 10.1177/0004867412437346.
8
Effect of levofloxacin on lithium - a pharmacokinetic study in rabbits.左氧氟沙星对锂的影响：兔体内的药代动力学研究。
Fundam Clin Pharmacol. 2013 Apr;27(2):181-5. doi: 10.1111/j.1472-8206.2011.00997.x. Epub 2011 Oct 17.
9
Review of lithium effects on brain and blood.锂对脑和血液影响的综述。
Cell Transplant. 2009;18(9):951-75. doi: 10.3727/096368909X471251. Epub 2009 May 13.
10
Drug-induced lithium toxicity in the elderly: a population-based study.老年人药物性锂中毒：一项基于人群的研究。
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锂中毒：与莫西沙星的一种可能相互作用。

Lithium Intoxication: A Possible Interaction with Moxifloxacin.

作者信息

Kayipmaz Selvi, Altınöz Ali Ercan, Ok Nadide Elmas Gülcü

机构信息

Department of Psychiatry, Baskent University Faculty of Medicine, Ankara, Turkey.

出版信息

Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):407-409. doi: 10.9758/cpn.2017.15.4.407.

DOI:10.9758/cpn.2017.15.4.407
PMID:29073753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5678478/
Abstract

Lithium is a well-known treatment for patients with mood disorders. Intoxication by lithium may be lethal particularly in elderly due to altered pharmacokinetics, renal impairment or multiple drug use. We presented a 74-year-old female patient who had been stabile with lithium carbonate 600 mg/day for 5 years and developed lithium intoxication after bronchiolitis. She presented with altered mental status. The neurological signs resolved slowly after lithium and moxifloxacin were stopped immediately and fluid resuscitation administered. Considering possible drug interactions on elderly patients receiving lithium is essential.

摘要

锂是治疗情绪障碍患者的一种知名药物。锂中毒可能是致命的，尤其是在老年人中，这是由于药代动力学改变、肾功能损害或多种药物联用所致。我们报告了一名74岁女性患者，她服用碳酸锂600毫克/天，病情稳定达5年，在患细支气管炎后发生锂中毒。她出现了精神状态改变。在立即停用锂和莫西沙星并给予液体复苏后，神经体征缓慢消退。考虑锂对老年患者可能存在的药物相互作用至关重要。