Kayipmaz Selvi, Altınöz Ali Ercan, Ok Nadide Elmas Gülcü
Department of Psychiatry, Baskent University Faculty of Medicine, Ankara, Turkey.
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):407-409. doi: 10.9758/cpn.2017.15.4.407.
Lithium is a well-known treatment for patients with mood disorders. Intoxication by lithium may be lethal particularly in elderly due to altered pharmacokinetics, renal impairment or multiple drug use. We presented a 74-year-old female patient who had been stabile with lithium carbonate 600 mg/day for 5 years and developed lithium intoxication after bronchiolitis. She presented with altered mental status. The neurological signs resolved slowly after lithium and moxifloxacin were stopped immediately and fluid resuscitation administered. Considering possible drug interactions on elderly patients receiving lithium is essential.
锂是治疗情绪障碍患者的一种知名药物。锂中毒可能是致命的,尤其是在老年人中,这是由于药代动力学改变、肾功能损害或多种药物联用所致。我们报告了一名74岁女性患者,她服用碳酸锂600毫克/天,病情稳定达5年,在患细支气管炎后发生锂中毒。她出现了精神状态改变。在立即停用锂和莫西沙星并给予液体复苏后,神经体征缓慢消退。考虑锂对老年患者可能存在的药物相互作用至关重要。