Hachinski V, Shibuya M, Norris J W, Hornykiewicz O
J Neural Transm Suppl. 1978(14):45-50.
Cerebrospinal fluid (CSF) homovanillic acid (HVA) concentration was measured in 39 consecutive cases of hemispheric infarction, 7 cases of brainstem infarction, and in 16 controls. The CSF-HVA level was 38 +/- 15 ng/ml (mean +/- S.D.) in the control patients, 15 +/- 6 ng/ml in patients with brainstem infarcts, and 49 +/- 41 ng/ml in those with hemispheric infarcts. The CSF-HVA levels were decreased in brainstem infarct cases (p less than 0.001) and greatly scattered in patients with hemispheric infarcts (range 4--207 ng/ml) when compared to controls. The decrease of levels of CSF-HVA in brainstem infarct cases may reflect interference with the dopaminergic pathways. CSF-HVA values in hemispheric infarction could not be related to the acuteness, location, nor severity of the lesion. The broad range of CSF-HVA values may be due to the interaction of multiple, as yet unknown factors. These findings suggest that dopamine metabolism is altered in many cases with acute brain infarction.
对39例连续的半球梗死患者、7例脑干梗死患者以及16名对照者测量了脑脊液（CSF）中高香草酸（HVA）的浓度。对照患者的脑脊液HVA水平为38±15 ng/ml（均值±标准差），脑干梗死患者为15±6 ng/ml，半球梗死患者为49±41 ng/ml。与对照相比，脑干梗死病例的脑脊液HVA水平降低（p<0.001），半球梗死患者的脑脊液HVA水平差异很大（范围为4 - 207 ng/ml）。脑干梗死病例中脑脊液HVA水平的降低可能反映了多巴胺能通路受到干扰。半球梗死患者的脑脊液HVA值与病变的急性程度、位置或严重程度无关。脑脊液HVA值的广泛范围可能是由于多种未知因素的相互作用。这些发现表明，在许多急性脑梗死病例中多巴胺代谢发生了改变。
