维生素D缺乏与糖尿病视网膜病变之间的关系：一项荟萃分析。

Relationship between vitamin D deficiency and diabetic retinopathy: a meta-analysis.

作者信息

Zhang Jason, Upala Sikarin, Sanguankeo Anawin

机构信息

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT.

Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand..

出版信息

Can J Ophthalmol. 2017 Nov;52 Suppl 1:S39-S44. doi: 10.1016/j.jcjo.2017.09.026.

DOI:10.1016/j.jcjo.2017.09.026

PMID:29074012

Abstract

OBJECTIVE

The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency.

DESIGN

Meta-analysis.

METHODS

We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis.

RESULTS

There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1.27 (95% CI, 1.17-1.37; P = 0.001; I = 80%; P = 0.01). There was also a statistically significant lower serum vitamin D level in patient subgroups with DR versus control groups, with an overall mean difference of -1.32 ng/mL (95% CI, -2.50 to -0.15; P = 0.001; I = 89%; P = 0.01).

CONCLUSION

There is a statistically significant association between vitamin D deficiency and DR.

摘要

目的

本研究旨在评估糖尿病视网膜病变（DR）与维生素D缺乏之间关联的证据。

设计

荟萃分析。

方法

我们纳入了14项观察性研究，共10007名参与者，这些参与者均接受了DR和维生素D缺乏的评估。采用随机效应Mantel-Haenszel分析计算合并比值比（OR）和95%置信区间（CI）。

结果

DR与维生素D缺乏之间存在统计学显著关联，总体合并OR为1.27（95%CI，1.17 - 1.37；P = 0.001；I² = 80%；P = 0.01）。与对照组相比，DR患者亚组的血清维生素D水平也存在统计学显著降低，总体平均差异为 -1.32 ng/mL（95%CI，-2.50至 -0.15；P = 0.001；I² = 89%；P = 0.01）。