Institute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital, Milan, Italy.
Endocrine. 2021 Apr;72(1):1-11. doi: 10.1007/s12020-021-02671-8. Epub 2021 Mar 18.
Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease.
Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19.
This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.
维生素 D 及其缺乏最近被怀疑与 COVID-19 的易感性增加和不良结局有关。这一假设是基于维生素 D 众所周知的免疫调节作用，以及 COVID-19 住院患者中 25 羟维生素 D（25OHD）水平持续较低的一致发现。此外，几项研究报告了 25OHD 水平与疾病不同临床结局之间的相关性。
本综述旨在从不同角度探讨维生素 D 与 COVID-19 的关系，总结导致 COVID-19 存在内分泌表型证据的数据。
本综述根据现有知识分析了 COVID-19 的几种内分泌表现可能在维生素 D 状态不足的情况下整体被解释为一个统一的现象。
