升压和血液稀释反应可补偿蓝鱼的急性出血。

Pressor and hemodilution responses compensate for acute hemorrhage in bluefish.

Ogilvy C S, Tremml P G, DuBois A B

John B. Pierce Foundation Laboratory, New Haven, CT 06519.

Comp Biochem Physiol A Comp Physiol. 1988;91(4):807-13. doi: 10.1016/0300-9629(88)90968-1.

Abstract

After hemorrhage of 21% blood volume (0.9% body weight) blood pressure (BP) and heart rate (H.R.) of unanesthetized bluefish (Pomatomus saltatrix) recovered within 5 min. 2. Phentolamine blocked this recovery. 3. Atropine increased control H.R. from 48 to 87 per min, and to 108 after hemorrhage, with delay of BP recovery to 10 min. 4. With small, repeated hemorrhages every 20 min, hemodilution and recovery of BP occurred between hemorrhages. Removal of 27% blood volume resulted in only temporary recovery. 5. Thirty min after hemorrhage, plasma epinephrine was 5 x and norepinephrine 8 x control. 6. Thus, bluefish tolerate hemorrhage with initial vasoconstriction via alpha-adrenergic pathways, and hemodilution.

摘要

在失血量达到血容量的21%（0.9%体重）后，未麻醉的蓝鱼（Pomatomus saltatrix）的血压（BP）和心率（H.R.）在5分钟内恢复。2. 酚妥拉明可阻断这种恢复。3. 阿托品使对照心率从每分钟48次增加到87次，出血后增加到108次，血压恢复延迟至10分钟。4. 每20分钟进行小剂量、反复出血，出血期间会发生血液稀释和血压恢复。失血27%的血容量仅导致暂时恢复。5. 出血30分钟后，血浆肾上腺素是对照的5倍，去甲肾上腺素是对照的8倍。6. 因此，蓝鱼通过α-肾上腺素能途径进行初始血管收缩和血液稀释来耐受出血。