Masuyama Ritsuko
Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, Japan.
Clin Calcium. 2017;27(11):1525-1532.
Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1α,25(OH)D]transported to the target organs, where the vitamin D receptor(VDR)is present. The biological significance of 1α,25(OH)D-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic β cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Although 1α,25(OH)D-VDR signalling in classical target organs of vitamin D has been extensively studied, its precise function in these target organs still needs further investigation.
维生素D内分泌系统对于骨骼和矿物质稳态是必需的，这一过程通过活性形式的维生素D[1α,25(OH)D]转运至存在维生素D受体（VDR）的靶器官来实现。1α,25(OH)D-VDR信号传导的生物学意义不仅体现在参与钙和磷稳态的维生素D的经典靶器官，如肠道、骨骼、肾脏和甲状旁腺中，还体现在维生素D的许多其他非经典靶细胞中，包括皮肤角质形成细胞、胰腺β细胞、心肌细胞、T淋巴细胞、骨髓巨噬细胞等。尽管维生素D经典靶器官中的1α,25(OH)D-VDR信号传导已得到广泛研究，但其在这些靶器官中的精确功能仍需进一步研究。
