Ao Tomoka, Kikuta Junichi, Ishii Masaru
Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Japan.
Clin Calcium. 2017;27(11):1551-1559.
Various kinds of immune cells -including dendritic cells, macrophages, T cells and B cells- express the vitamin D receptor and 1α-hydroxylase(CYP27B1). studies have shown the anti-inflammatory effect of 1,25-dihydroxyvitamin D:the active form of vitamin D. As vitamin D deficiency spread in our society, epidemiological studies have established the association between vitamin D deficiency and incidence or progression of several inflammatory diseases, including rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), and multiple sclerosis(MS). In addition, recently the property of vitamin D for treatment or prevention is debated. Here, we review the recent epidemiological evidence associated with vitamin D and inflammatory diseases, and describe the immunomodulatory effect of vitamin D underlying it.
包括树突状细胞、巨噬细胞、T细胞和B细胞在内的各种免疫细胞都表达维生素D受体和1α-羟化酶（CYP27B1）。研究表明，维生素D的活性形式1,25-二羟基维生素D具有抗炎作用。随着维生素D缺乏在我们社会中的蔓延，流行病学研究已证实维生素D缺乏与包括类风湿性关节炎（RA）、系统性红斑狼疮（SLE）和多发性硬化症（MS）在内的几种炎症性疾病的发病率或进展之间存在关联。此外，最近关于维生素D治疗或预防的特性也存在争议。在此，我们综述了与维生素D和炎症性疾病相关的最新流行病学证据，并描述了其背后的维生素D免疫调节作用。
