Department of Stomatology, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Pediatrics, Pediatric Research Institute, The University of Louisville School of Medicine, Louisville, KY, United States.
Front Endocrinol (Lausanne). 2020 Aug 7;11:536. doi: 10.3389/fendo.2020.00536. eCollection 2020.
Diabetes mellitus, a major chronic disease affecting human health, has been increasing in prevalence in recent years. Diabetes mellitus can cause bone metabolic disorders in patients, leading to osteoporosis, a higher risk of traumatic fracture, and other bone diseases. Bone metabolic disorders in the oral cavity principally manifest as periodontitis, loss of alveolar bone, and failure of implant osseointegration. In recent years, numerous studies have shown that there is a complex interaction between bone metabolic disorders and diabetes mellitus. This paper reviews the adverse effects of diabetes on oral bone metabolism disorders such as alveolar osteoporosis and bone loss in patients with periodontitis, discusses the potential mechanisms of diabetic bone loss, and suggests potential ways to prevent and treat oral bone loss in patients with diabetes mellitus.
糖尿病是一种严重影响人类健康的慢性疾病，近年来其发病率不断上升。糖尿病可引起患者的骨代谢紊乱，导致骨质疏松症、创伤性骨折风险增加和其他骨疾病。口腔骨代谢紊乱主要表现为牙周炎、牙槽骨丧失和种植体骨整合失败。近年来，大量研究表明，骨代谢紊乱和糖尿病之间存在复杂的相互作用。本文综述了糖尿病对牙周炎患者牙槽骨质疏松症和骨丢失等口腔骨代谢紊乱的不良影响，探讨了糖尿病性骨丢失的潜在机制，并提出了预防和治疗糖尿病患者口腔骨丢失的潜在方法。
