Kaneko Ichiro, Miyamoto Ken-Ichi, Nikawa Takeshi
Department of Molecular Nutrition, Tokushima University Graduate School, Japan.
Department of Nutritional Physiology, Tokushima University Graduate School, Japan.
Clin Calcium. 2017;27(11):1571-1578.
In elderly people, vitamin D insufficiency may increase the risk of fracture, and may also be involved in the development of sarcopenia or cardiovascular decline. Recent studies using vitamin D receptor knockout mice unveiled multiple functions of vitamin D beyond bone and mineral metabolism. This review describes the actions of vitamin D in skeletal, cardiac, and vascular smooth muscle. Eldecalcitol, an active vitamin D analog developed for the treatment of osteoporosis, also effectively improved skeletal muscle function , and may have synergistic activities in bone and muscle. Maintaining an optimal vitamin D status protects against fracture, and is expected to have beneficial effects for improving chronic diseases accompanied by muscle function abnormalities.
在老年人中,维生素D不足可能会增加骨折风险,还可能与肌肉减少症或心血管功能衰退的发生有关。最近使用维生素D受体敲除小鼠的研究揭示了维生素D在骨骼和矿物质代谢之外的多种功能。这篇综述描述了维生素D在骨骼、心脏和血管平滑肌中的作用。 eldecalcitol是一种为治疗骨质疏松症而开发的活性维生素D类似物,它也能有效改善骨骼肌功能,并且可能在骨骼和肌肉中具有协同作用。维持最佳的维生素D状态可预防骨折,并有望对改善伴有肌肉功能异常的慢性疾病产生有益影响。