内皮细胞衍生产物对血管通透性的局部调节作用。
The local modulation of vascular permeability by endothelial cell derived products.
作者信息
Chander C L, Moore A R, Desa F M, Howat D, Willoughby D A
机构信息
Department of Experimental Pathology, St Bartholomew's Hospital Medical College, London, UK.
出版信息
J Pharm Pharmacol. 1988 Oct;40(10):745-6. doi: 10.1111/j.2042-7158.1988.tb07011.x.
Endothelin has been shown to suppress increased vascular permeability in the rat at doses of 0.01 pmol. The agonists used were nitric oxide and nitroprusside, which have the same activity as endothelial-derived relaxing factor. Histamine, 5-hydroxytryptamine, platelet activating factor and carrageenan were the other agonists used. It is proposed that endothelin and EDRF act as local hormones produced by endothelial cells to control local vascular permeability.
已证明内皮素在剂量为0.01皮摩尔时可抑制大鼠血管通透性增加。所使用的激动剂为一氧化氮和硝普钠，它们具有与内皮源性舒张因子相同的活性。组胺、5-羟色胺、血小板活化因子和角叉菜胶是其他所使用的激动剂。有人提出，内皮素和内皮源性舒张因子作为内皮细胞产生的局部激素，以控制局部血管通透性。
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