Winkle S A, Crooks P A
Department of Chemistry, Rutgers University, Piscataway, NJ 08855.
J Pharm Pharmacol. 1988 Nov;40(11):809-11. doi: 10.1111/j.2042-7158.1988.tb05179.x.
Studies using the solute-enhanced phase partition technique demonstrate that the endogenous amines histamine and spermine bind to both salmon sperm DNA and poly(dGdC) in a markedly cooperative fashion. Both compounds exhibited DNA sequence-dependence effects in their mode of binding. The linear aliphatic spermine molecule binds more strongly than histamine to both DNA types.
使用溶质增强相分配技术的研究表明，内源性胺类组胺和精胺以明显协同的方式与鲑鱼精子DNA和聚（dGdC）结合。两种化合物在结合模式上均表现出DNA序列依赖性效应。线性脂肪族精胺分子对两种DNA类型的结合都比组胺更强。
