Candenas M L, Anselmi E
Departamento de Farmacología y Farmacotecnia (Farmacognosia y Farmacodinamia) Facultad de Farmacia, Valencia, España.
Rev Esp Fisiol. 1988 Dec;44(4):375-9.
Relaxation responses to the beta-adrenoceptor agonists: isoprenaline (non selective), salbutamol (beta 2-selective) and noradrenaline (plus phentolamine 10(-5) M) (beta 1-selective) have been obtained on rat lung parenchymal strips in the absence and presence of pargyline and tropolone (monoamino-oxidase and catechol-O-methyltransferase inhibitors), cocaine (neuronal uptake blocking agent), corticosterone (extraneuronal uptake inhibitor) as well as in reserpinized rat. Responses to these beta-adrenergic agonists were not potentiated in the presence of any of these inhibitors. This indicates that endogenous catecholamines, enzymatic or uptake processes, do not modulate beta-adrenoceptor mediated responses of rat lung strip and demonstrates that there is no correlation between neuronal uptake/beta 1-adrenoceptors and extraneuronal uptake/beta 2-adrenoceptor mediated responses, as had previously been suggested.
对β-肾上腺素能激动剂的松弛反应：在不存在和存在帕吉林和托酚酮（单胺氧化酶和儿茶酚-O-甲基转移酶抑制剂）、可卡因（神经元摄取阻断剂）、皮质酮（非神经元摄取抑制剂）的情况下，以及在利血平化大鼠中，已在大鼠肺实质条上获得了对异丙肾上腺素（非选择性）、沙丁胺醇（β2-选择性）和去甲肾上腺素（加酚妥拉明10(-5)M）（β1-选择性）的松弛反应。在存在任何这些抑制剂的情况下，对这些β-肾上腺素能激动剂的反应均未增强。这表明内源性儿茶酚胺、酶促或摄取过程不会调节大鼠肺条中β-肾上腺素能受体介导的反应，并证明如先前所提出的，神经元摄取/β1-肾上腺素能受体与非神经元摄取/β2-肾上腺素能受体介导的反应之间不存在相关性。
