Afreen Bahjat, Khan Khurshid Ahmed, Riaz Amna
Medicine Department, Jinnah Hospital/Allama Iqbal Medical College, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2017 Jul-Sep;29(3):428-431.
Adrenal insufficiency (AI) is the most common endocrine complication among patients with AIDS/HIV infection and there are number of causes of AI in HIV patients. Human immunodeficiency virus directly as well as indirectly destroys adrenal glands. The estimates of its prevalence and severity vary. AI is the most life threatening but readily correctable endocrine complication that occurs in persons with HIV infection. This study was carried out to determine the frequency of Adrenal Insufficiency in HIV patients and their clinical features as proper diagnosis and timely treatment have been shown to improve quality of life and long-term mortality in AIDS patients.
It was a cross sectional survey conducted at HIV clinic and Jinnah Allama Iqbal Institute of Diabetes and Endocrinology, Jinnah Hospital Lahore. Sixty-four HIV positive patients, both male and female, aged above 15 years were included in the study. HIV patients who had recently taken steroids, ketoconazole or rifampicin, determined on history, were excluded from the study. The data was collected on a structured proforma and analysis was performed in SPSS-21.0. Frequency and percentages for adrenal insufficiency and its characteristics were calculated. Chi-square test was used with p<0.05 as statistically significant.
In this study, 9 (14.06%) HIV patients were diagnosed with adrenal insufficiency, male to female ratio was 3.5:1 and AI was found statistically significantly associated with fatigue (p<0.008) and weight loss (p<0.001).
Adrenal insufficiency was high among the patients with HIV, it was not gender specific but it was found to be associated with fatigue and weight loss.
肾上腺功能不全（AI）是艾滋病/艾滋病毒感染患者中最常见的内分泌并发症，艾滋病毒患者发生AI有多种原因。人类免疫缺陷病毒直接或间接破坏肾上腺。其患病率和严重程度的估计各不相同。AI是艾滋病毒感染者中最危及生命但易于纠正的内分泌并发症。本研究旨在确定艾滋病毒患者中肾上腺功能不全的发生率及其临床特征，因为已证明正确诊断和及时治疗可改善艾滋病患者的生活质量和长期死亡率。
这是一项在拉合尔真纳医院的艾滋病毒诊所和真纳·阿拉马·伊克巴尔糖尿病与内分泌研究所进行的横断面调查。研究纳入了64名年龄在15岁以上的艾滋病毒阳性患者，男女均有。根据病史确定近期服用过类固醇、酮康唑或利福平的艾滋病毒患者被排除在研究之外。数据通过结构化表格收集，并在SPSS-21.0中进行分析。计算肾上腺功能不全及其特征的频率和百分比。使用卡方检验，p<0.05为具有统计学意义。
在本研究中，9名（14.06%）艾滋病毒患者被诊断为肾上腺功能不全，男女比例为3.5:1，且发现AI与疲劳（p<0.008）和体重减轻（p<0.001）在统计学上显著相关。
艾滋病毒患者中肾上腺功能不全的发生率较高，它不具有性别特异性，但与疲劳和体重减轻有关。
