Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
Curr Opin Psychiatry. 2018 Jan;31(1):26-31. doi: 10.1097/YCO.0000000000000378.
The principal aim of this review is to highlight recent advances in our understanding of cognitive dysfunction in major depressive disorder (MDD). We review new assessment and treatment approaches, in which cognition and associated psychosocial dysfunction are considered primary outcomes.
Current work suggests that cognitive dysfunction reduces occupational productivity, and interferes broadly with domains of day-to-day and social functioning. These findings imply that cognitive dysfunction interacts with emotional and social factors relevant to MDD. Recent advances in screening instruments enable standardized detection of cognitive symptoms in MDD. Clinical trials suggest that cognitive symptoms are suitable targets and primary outcomes of psychological and pharmacological treatments.
A growing interest in cognitive dysfunction in MDD has improved our ability to assess and treat MDD. Future research will be strengthened by the use of consistent terminology, standardized cognitive screening, and treatments that target cognitive dysfunction in MDD. Integration of emotional and social treatment strategies may further advance clinical efficacy.
本文的主要目的是强调对重度抑郁症（MDD）认知功能障碍的理解的最新进展。我们综述了新的评估和治疗方法，其中认知功能和相关的心理社会功能障碍被视为主要结果。
目前的研究表明，认知功能障碍降低了职业生产力，并广泛干扰了日常和社会功能领域。这些发现表明，认知功能障碍与 MDD 相关的情绪和社会因素相互作用。目前的筛查工具的进步使得在 MDD 中标准化地检测认知症状成为可能。临床试验表明，认知症状是心理和药物治疗的合适目标和主要结果。
对 MDD 认知功能障碍的日益关注提高了我们评估和治疗 MDD 的能力。未来的研究将通过使用一致的术语、标准化的认知筛查以及针对 MDD 认知功能障碍的治疗方法得到加强。将情绪和社会治疗策略结合起来可能会进一步提高临床疗效。
