Barquet-Muñoz Salim Abraham, Cruz-Rodríguez Efraín, Cantú De León David Francisco, Isla-Ortiz David, Montalvo-Esquivel Gonzalo, Herrera-Montalvo Luis Alonso, Pérez-Plasencia Carlos, Pérez-Montiel Delia, Herrera-Gómez Ángel
Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexicoo.
Rev Invest Clin. 2017 Sep-Oct;69(5):286-292. doi: 10.24875/ric.17002143.
Cervical carcinoma (CC) is one of the most frequent neoplasms, especially in developing countries. The most common histopathological type is squamous cell carcinoma (SCC), followed by adenocarcinoma (AC) and adenosquamous carcinoma (ASC). Prognosis according to histological type is controversial.
The objective of this study is to describe and compare the prognoses of the most common histologies of CC in the early stages.
We reviewed records of patients attended at the Instituto Nacional de Cancerología of Mexico with CC surgically treated Stages IA2-IB1 and IIA1, including the histological types SCC, AC, and ASC. Patients who had another malignant neoplasm, cervical cancer in situ, locally advanced neoplasm, and metastatic neoplasm were excluded from the study. A descriptive and comparative analysis was conducted. Overall survival (OS) and disease-free period were calculated for each histological type with the Kaplan-Meier method and were compared with the log-rank test.
A total of 202 records were obtained, of which 131 (64.9%) had SCC, 57 (28.2%) AC, and 14 (6.9%) ASC. The 5-year DFS was 94.4% for SCC, 98.1% for AC, and 92.3% for ASC, without a statistically significant difference (p = 0.55). The 5-year OS for SCC was 97.9%, for AC was 97.8%, and for ASC was 100%, without a statistically significant difference (p = 0.702).
DFS and OS did not differ between the most common histological types of CC at the early stages.
宫颈癌（CC）是最常见的肿瘤之一，尤其是在发展中国家。最常见的组织病理学类型是鳞状细胞癌（SCC），其次是腺癌（AC）和腺鳞癌（ASC）。根据组织学类型判断的预后存在争议。
本研究的目的是描述和比较早期CC最常见组织学类型的预后。
我们回顾了在墨西哥国家癌症研究所接受手术治疗的IA2 - IB1期和IIA1期CC患者的记录，包括组织学类型SCC、AC和ASC。患有其他恶性肿瘤、宫颈原位癌、局部晚期肿瘤和转移性肿瘤的患者被排除在研究之外。进行了描述性和对比性分析。采用Kaplan - Meier方法计算每种组织学类型的总生存期（OS）和无病生存期，并通过对数秩检验进行比较。
共获得202份记录，其中131例（64.9%）为SCC，57例（28.2%）为AC，14例（6.9%）为ASC。SCC的5年无病生存率为94.4%，AC为98.1%，ASC为92.3%，差异无统计学意义（p = 0.55）。SCC的5年总生存率为97.9%，AC为97.8%，ASC为100%，差异无统计学意义（p = 0.702）。
早期CC最常见组织学类型之间的无病生存期和总生存期无差异。
