Reiffers J, Boiron J M, Marit G, Bouzgarrou R, Bernard P, David B, Foures C, Broustet A, Vezon G
Unité de Greffe, CHR Bordeaux, Hôpital Haut-Lévêque, Pessac.
Ann Med Interne (Paris). 1988;139 Suppl 1:3-6.
Peripheral blood stem cells were collected from 50 patients with different hematological malignancies. Leukaphereses (n = 263) were performed during the marrow regeneration phase following different types of chemotherapy. The mean number of CFU-GM collected per leukapheresis was 486 x 10(4), highest levels of CFU-GM being obtained in patients who received the most intensive chemotherapy and who had not been treated previously. Twenty-five patients underwent autologous blood stem cell transplantation. Hemopoietic recovery was complete and prompt in 24 patients. Only one patient had no megakaryocytic engraftment. These findings indicate that peripheral blood stem cells may be used for autologous transplantation in leukemic patients.
从50例不同血液系统恶性肿瘤患者中采集外周血干细胞。在不同类型化疗后的骨髓再生期进行白细胞分离术（n = 263）。每次白细胞分离术收集的CFU - GM平均数量为486×10⁴，在接受最强化疗且此前未接受过治疗的患者中获得了最高水平的CFU - GM。25例患者接受了自体造血干细胞移植。24例患者造血恢复完全且迅速。只有1例患者没有巨核细胞植入。这些发现表明外周血干细胞可用于白血病患者的自体移植。
