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骨髓增殖性疾病

Myeloproliferative Disorders.

作者信息

Meier Brian, Burton John H

机构信息

Department of Emergency Medicine, Carilion Clinic, 525 Janette Avenue Southwest, Roanoke, VA 24016, USA.

Department of Emergency Medicine, Carilion Clinic, PO Box 13367, Roanoke, VA 24033, USA.

出版信息

Hematol Oncol Clin North Am. 2017 Dec;31(6):1029-1044. doi: 10.1016/j.hoc.2017.08.007.

Abstract

The emergency providers generally encounters myeloproliferative disorders (MPNs) in 1 of 2 ways: as striking laboratory abnormalities of seeming unknown consequence, or in previously diagnosed patients presenting with complications. The course of patients with MPNs is highly variable, but major complications can arise. Emergent conditions related to hyperviscosity need to be recognized early and treated aggressively. Rapid hydration, transfusion, cytoreduction, and early hematology consultation can be lifesaving. Likewise, although management is not altered, a high index of suspicion for thrombotic complications is required in patients with known MPNs as these are a significant cause of morbidity and mortality.

摘要

急诊医护人员通常通过以下两种方式之一遇到骨髓增殖性疾病(MPN):一是作为看似后果不明的显著实验室异常情况,二是在已确诊的患者出现并发症时。MPN患者的病程差异很大,但可能会出现严重并发症。与高粘滞血症相关的紧急情况需要尽早识别并积极治疗。快速补液、输血、细胞减灭以及早期血液学会诊可能挽救生命。同样,尽管管理方式不变,但对于已知患有MPN的患者,需要高度怀疑血栓形成并发症,因为这些是发病和死亡的重要原因。

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