Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassemia major: the DEEP-3 multi-center observational safety study.
作者信息
Botzenhardt Sebastian, Felisi Mariagrazia, Bonifazi Donato, Del Vecchio Giovanni C, Putti Maria C, Kattamis Antonis, Ceci Adriana, Wong Ian C K, Neubert Antje
机构信息
Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, Friedrich-Alexander University Erlangen-Nurnberg (FAU), Erlangen, Germany.
Consorzio per Valutazioni Biologiche e Farmacologiche, Pavia, Italy.
出版信息
Haematologica. 2018 Jan;103(1):e1-e4. doi: 10.3324/haematol.2017.176065. Epub 2017 Oct 27.
Abstract
摘要
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本文引用的文献
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Eur J Haematol. 2017 Mar;98(3):198-217. doi: 10.1111/ejh.12833. Epub 2017 Jan 19.
2
Deferiprone-induced agranulocytosis: 20 years of clinical observations.去铁酮诱导的粒细胞缺乏症：20年临床观察
Am J Hematol. 2016 Oct;91(10):1026-31. doi: 10.1002/ajh.24479. Epub 2016 Aug 4.
3
Safety Profile of Oral Iron Chelator Deferiprone in Chinese Children with Transfusion-Dependent Thalassaemia.口服铁螯合剂去铁酮在中国依赖输血的地中海贫血儿童中的安全性概况
Curr Drug Saf. 2016;11(2):137-44. doi: 10.2174/1574886310666150930113957.
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Deviating from safety guidelines during deferiprone therapy in clinical practice may not be associated with higher risk of agranulocytosis.在临床实践中，偏离地拉罗司治疗的安全指南可能与粒细胞缺乏症风险的增加无关。
Pediatr Blood Cancer. 2014 May;61(5):879-84. doi: 10.1002/pbc.24920. Epub 2013 Dec 30.
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Continuation of deferiprone therapy in patients with mild neutropenia may not lead to a more severe drop in neutrophil count.轻度中性粒细胞减少症患者继续使用去铁酮治疗可能不会导致中性粒细胞计数出现更严重的下降。
Eur J Haematol. 2014 Apr;92(4):337-40. doi: 10.1111/ejh.12241. Epub 2014 Jan 30.
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