Takahashi Taku
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, Tsushimanaka 3-1-1, kita-ku, 700-8530, Okayama, Japan.
Methods Mol Biol. 2018;1694:51-59. doi: 10.1007/978-1-4939-7398-9_4.
Themospermine is a structural isomer of spermine and is present in some bacteria and most of plants. An Arabidopsis mutant, acaulis5 (acl5), that is defective in the biosynthesis of thermospermine displays excessive proliferation of xylem vessels with dwarfed growth. Recent studies using acl5 and its suppressor mutants that recover the growth without thermospermine have revealed that thermospermine plays a key role in the negative control of the proliferation of xylem vessels through enhancing translation of specific mRNAs that contain a conserved upstream open-reading-frame (uORF) in the 5' leader region.
热精胺是精胺的结构异构体，存在于一些细菌和大多数植物中。拟南芥突变体茎生叶5（acl5）在热精胺生物合成方面存在缺陷，表现出木质部导管过度增殖且生长矮小。最近利用acl5及其抑制突变体（这些突变体在没有热精胺的情况下恢复生长）进行的研究表明，热精胺通过增强特定mRNA的翻译在木质部导管增殖的负调控中起关键作用，这些mRNA在5'前导区含有一个保守的上游开放阅读框（uORF）。
