Paediatric Research Group, University of Tromsø, Tromsø, Norway.
Telelab AS, Skien, Norway.
Acta Paediatr. 2018 Mar;107(3):490-495. doi: 10.1111/apa.14135. Epub 2017 Nov 15.
We examined children hospitalised for invasive meningococcal disease, a leading cause of paediatric sepsis, in Troms County, North Norway, from 1973 to 2016, including the epidemic in the 1970s and 1980s.
This study was a retrospective review of children under the age of 15 years who were hospitalised for meningococcal disease at the University Hospital of North Norway and Harstad Hospital. We studied hospital and bacteriological records to determine the incidence rates and phenotypes involved.
There were 300 cases under 15 years and an incidence rate of 17 per 100,000 cases for 1973-2016. This was broken down into the following: 1973-1980 (n = 130, 49), 1981-1990 (n = 129, 39), and 1991-2016 (n = 41, 4.7), respectively. There were 21 (7%) deaths. Phenotype B:15:P1.7,16 was more common than the other phenotypes in the epidemic period before 1990 than after 1990 (p = 0.02) and had a significantly lower mortality rate than the other phenotypes (p = 0.04). Later years showed a more heterogenous phenotype distribution. Serogroup B was the dominant serogroup.
The B:15:P1.7,6 strain was more prevalent during the Norwegian epidemic of invasive meningococcal disease, but had a significantly lower mortality rate. The phenotype distribution was more heterogeneous after 1990. The dominant serogroup was B.
我们研究了 1973 年至 2016 年期间在挪威特罗姆瑟县因侵袭性脑膜炎球菌病住院的儿童，这是小儿败血症的主要病因，包括 70 年代和 80 年代的流行情况。
本研究是对在挪威北特罗姆瑟大学医院和哈斯塔德医院因脑膜炎球菌病住院的 15 岁以下儿童进行的回顾性研究。我们研究了医院和细菌学记录，以确定所涉及的发病率和表型。
在 1973 年至 2016 年期间，有 300 例 15 岁以下儿童，发病率为每 100,000 例 17 例。具体情况如下：1973-1980 年（n = 130，49），1981-1990 年（n = 129，39），1991-2016 年（n = 41，4.7）。有 21 例（7%）死亡。表型 B：15：P1.7，16 在 1990 年之前的流行期间比之后更为常见（p = 0.02），且死亡率明显低于其他表型（p = 0.04）。后来的年份表现出更为异质的表型分布。B 群是主要的血清群。
在挪威侵袭性脑膜炎球菌病流行期间，B：15：P1.7，6 菌株更为流行，但死亡率明显较低。1990 年后，表型分布更加多样化。主要的血清群是 B 群。
