Looij B J, Roelfsema F, van der Heide D, Frölich M, Souverijn J H, Nieuwenhuijzen Kruseman A C
Department of Endocrinology, University Hospital, Leiden, The Netherlands.
Clin Endocrinol (Oxf). 1988 Nov;29(5):517-27. doi: 10.1111/j.1365-2265.1988.tb03701.x.
To determine whether human calcitonin inhibits GH secretion in man, as has been described for salmon calcitonin, the effect of an i.v. bolus of human calcitonin or saline on GH release after either insulin-induced hypoglycaemia or the administration of GH-releasing hormone (GHRH) or saline was studied. After the injection of calcitonin, no spontaneous GH surges were seen; the GH response to hypoglycaemia was diminished and the response to GHRH almost completely suppressed. Administration of calcitonin also caused a small and transient rise in plasma PRL and TSH but not LH levels, and no change in the integrated PRL or TSH response. Calcium and magnesium levels did not change. It is concluded that human calcitonin suppresses GH secretion in man, but not by suppressing GHRH and probably not by increasing somatostatin release. In addition, calcitonin has limited PRL and TSH-releasing activity.
为了确定人降钙素是否像鲑鱼降钙素那样抑制人体内生长激素（GH）的分泌，研究了静脉注射人降钙素或生理盐水对胰岛素诱导的低血糖、生长激素释放激素（GHRH）或生理盐水给药后GH释放的影响。注射降钙素后，未观察到自发性GH峰值；对低血糖的GH反应减弱，对GHRH的反应几乎完全被抑制。降钙素给药还导致血浆催乳素（PRL）和促甲状腺激素（TSH）水平出现小幅短暂升高，但促黄体生成素（LH）水平未升高，PRL或TSH的综合反应也无变化。钙和镁水平未改变。结论是人降钙素抑制人体内GH分泌，但不是通过抑制GHRH，可能也不是通过增加生长抑素释放。此外，降钙素具有有限的PRL和TSH释放活性。
