• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

离子型受体 76b 是味觉对过量钠离子产生厌恶反应所必需的。

Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in .

机构信息

Samsung Medical Center, Department of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, Korea.

Dong-A ST Research Institute, Yongin 17073, Korea.

出版信息

Mol Cells. 2017 Oct;40(10):787-795. doi: 10.14348/molcells.2017.0160. Epub 2017 Oct 27.

DOI:10.14348/molcells.2017.0160
PMID:29081083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5682255/
Abstract

Avoiding ingestion of excessively salty food is essential for cation homeostasis that underlies various physiological processes in organisms. The molecular and cellular basis of the aversive salt taste, however, remains elusive. Through a behavioral reverse genetic screening, we discover that feeding suppression by Na-rich food requires () in labellar gustatory receptor neurons (GRNs). Concentrated sodium solutions with various anions caused feeding suppression dependent on . Feeding aversion to caffeine and high concentrations of divalent cations and sorbitol was unimpaired in -deficient animals, indicating sensory specificity of dependent Na detection and the irrelevance of hyperosmolarity-driven mechanosensation to -mediated feeding aversion. -dependent Na-sensing GRNs in both L- and s-bristles are required for repulsion as opposed to the previous report where the L-bristle GRNs direct only low-Na attraction. Our work extends the physiological implications of from low-Na attraction to high-Na aversion, prompting further investigation of the physiological mechanisms that modulate two competing components of Na-evoked gustation coded in heterogeneous -positive GRNs.

摘要

避免摄入过多的盐是维持生物体各种生理过程中阳离子稳态的关键。然而，令人讨厌的盐味的分子和细胞基础仍然难以捉摸。通过行为反向遗传筛选，我们发现在富含 Na 的食物抑制进食需要 () 在唇瓣味觉受体神经元 (GRNs) 中。具有各种阴离子的高浓度钠离子溶液会导致依赖 的进食抑制。在缺乏 的动物中，对咖啡因和高浓度二价阳离子和山梨糖醇的进食厌恶没有受到影响，这表明依赖 的 Na 检测具有感觉特异性，而高渗透压驱动的机械感觉与 - 介导的进食厌恶无关。L-和 s-刚毛中的 - 依赖性 Na 感应 GRNs 都需要排斥，而之前的报告表明，L-刚毛 GRNs 仅指导低 Na 吸引。我们的工作将 的生理意义从低 Na 吸引扩展到高 Na 厌恶，促使进一步研究调节 Na 诱发味觉中两种竞争成分的生理机制，这些成分由异质 - 阳性 GRNs 编码。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/198abd83f7b5/molce-40-10-787f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/a3bb091fef4f/molce-40-10-787f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/6e9fe90ec5bd/molce-40-10-787f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/c43d3d2a537c/molce-40-10-787f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/4397c3724c08/molce-40-10-787f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/78066fac6153/molce-40-10-787f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/198abd83f7b5/molce-40-10-787f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/a3bb091fef4f/molce-40-10-787f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/6e9fe90ec5bd/molce-40-10-787f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/c43d3d2a537c/molce-40-10-787f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/4397c3724c08/molce-40-10-787f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/78066fac6153/molce-40-10-787f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2751/5682255/198abd83f7b5/molce-40-10-787f6.jpg

相似文献

1
Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in .离子型受体 76b 是味觉对过量钠离子产生厌恶反应所必需的。
Mol Cells. 2017 Oct;40(10):787-795. doi: 10.14348/molcells.2017.0160. Epub 2017 Oct 27.
2
Histamine gustatory aversion in Drosophila melanogaster.黑腹果蝇中的组胺味觉厌恶
Insect Biochem Mol Biol. 2021 Jul;134:103586. doi: 10.1016/j.ibmb.2021.103586. Epub 2021 May 13.
3
The molecular basis for attractive salt-taste coding in Drosophila.果蝇中盐味吸引力编码的分子基础。
Science. 2013 Jun 14;340(6138):1334-8. doi: 10.1126/science.1234133.
4
Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons.离子型受体通过酸味味觉受体神经元介导果蝇产卵偏好。
Curr Biol. 2017 Sep 25;27(18):2741-2750.e4. doi: 10.1016/j.cub.2017.08.003. Epub 2017 Sep 7.
5
A Molecular and Cellular Context-Dependent Role for Ir76b in Detection of Amino Acid Taste.Ir76b在氨基酸味觉检测中的分子和细胞背景依赖性作用。
Cell Rep. 2017 Jan 17;18(3):737-750. doi: 10.1016/j.celrep.2016.12.071.
6
Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.离子型受体介导果蝇对含氮废物的回避。
Commun Biol. 2021 Nov 12;4(1):1281. doi: 10.1038/s42003-021-02799-3.
7
Molecular basis of fatty acid taste in .脂肪酸味觉的分子基础。
Elife. 2017 Dec 12;6:e30115. doi: 10.7554/eLife.30115.
8
Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila.表达离子型受体 94e 的味觉细胞在果蝇中相互影响摄食和产卵。
Cell Rep. 2024 Aug 27;43(8):114625. doi: 10.1016/j.celrep.2024.114625. Epub 2024 Aug 13.
9
Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines.离子型化学感应受体介导多胺的味觉和嗅觉。
PLoS Biol. 2016 May 4;14(5):e1002454. doi: 10.1371/journal.pbio.1002454. eCollection 2016 May.
10
A molecular mechanism for high salt taste in Drosophila.果蝇中高盐味觉的分子机制。
Curr Biol. 2022 Jul 25;32(14):3070-3081.e5. doi: 10.1016/j.cub.2022.06.012. Epub 2022 Jun 29.

引用本文的文献

1
Molecular Insights Into the Sensory Adaption of the Cave-Dwelling Leech to the Karst Cave Environment.洞穴水蛭对喀斯特洞穴环境的感官适应的分子见解
Ecol Evol. 2025 Jan 18;15(1):e70877. doi: 10.1002/ece3.70877. eCollection 2025 Jan.
2
Molecular and cellular basis of sodium sensing in labellum.唇瓣中钠感知的分子和细胞基础。
iScience. 2024 Jun 11;27(7):110248. doi: 10.1016/j.isci.2024.110248. eCollection 2024 Jul 19.
3
A single pair of pharyngeal neurons functions as a commander to reject high salt in .一对咽神经元作为指挥官拒绝高盐在 。

本文引用的文献

1
Ionotropic Receptor-dependent moist and dry cells control hygrosensation in .离子型受体依赖性的湿敏和干敏细胞控制着……中的湿度感知。 （原句结尾不完整）
Elife. 2017 Jun 16;6:e26654. doi: 10.7554/eLife.26654.
2
A Molecular and Cellular Context-Dependent Role for Ir76b in Detection of Amino Acid Taste.Ir76b在氨基酸味觉检测中的分子和细胞背景依赖性作用。
Cell Rep. 2017 Jan 17;18(3):737-750. doi: 10.1016/j.celrep.2016.12.071.
3
A molecular and neuronal basis for amino acid sensing in the Drosophila larva.果蝇幼虫中氨基酸感应的分子和神经元基础。
Elife. 2024 Apr 4;12:RP93464. doi: 10.7554/eLife.93464.
4
IR76b-expressing neurons in are necessary for associative reward learning of an amino acid mixture.表达 IR76b 的神经元对于混合氨基酸的联想性奖励学习是必需的。
Biol Lett. 2024 Feb;20(2):20230519. doi: 10.1098/rsbl.2023.0519. Epub 2024 Feb 14.
5
An inhibitory mechanism for suppressing high salt intake in Drosophila.果蝇抑制高盐摄入的抑制机制。
Chem Senses. 2023 Jan 1;48. doi: 10.1093/chemse/bjad014.
6
Molecular and functional basis of high-salt avoidance in a blood-sucking insect.一种吸血昆虫中高盐回避的分子和功能基础。
iScience. 2022 Jun 2;25(7):104502. doi: 10.1016/j.isci.2022.104502. eCollection 2022 Jul 15.
7
Meeting a threat of the Anthropocene: Taste avoidance of metal ions by .应对人类世的威胁：. 对金属离子的味觉回避。
Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2204238119. doi: 10.1073/pnas.2204238119. Epub 2022 Jun 14.
8
Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila.Ir56b 是一种非典型的离子型受体，它是果蝇中味觉盐反应的基础。
Curr Biol. 2022 Apr 25;32(8):1776-1787.e4. doi: 10.1016/j.cub.2022.02.063. Epub 2022 Mar 15.
9
Chemosensory Pathways as Potential Targets to Curb the Insect Menace.化学感应通路作为抑制昆虫威胁的潜在靶点
Insects. 2022 Jan 28;13(2):142. doi: 10.3390/insects13020142.
10
Effects of Mating on Gene Expression in Female Insects: Unifying the Field.交配对雌性昆虫基因表达的影响：整合该领域研究
Insects. 2022 Jan 7;13(1):69. doi: 10.3390/insects13010069.
Sci Rep. 2016 Dec 16;6:34871. doi: 10.1038/srep34871.
4
FlyBase at 25: looking to the future.《果蝇数据库25周年：展望未来》
Nucleic Acids Res. 2017 Jan 4;45(D1):D663-D671. doi: 10.1093/nar/gkw1016. Epub 2016 Oct 30.
5
Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in .不同组合的变异离子型谷氨酸受体介导了（某种生物）的温度感觉和湿度感觉。
Elife. 2016 Sep 22;5:e17879. doi: 10.7554/eLife.17879.
6
Nucleophile sensitivity of TRPA1 underlies light-induced feeding deterrence.TRPA1的亲核试剂敏感性是光诱导摄食抑制的基础。
Elife. 2016 Sep 22;5:e18425. doi: 10.7554/eLife.18425.
7
TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons.TMC-1通过伤害感受神经元介导秀丽隐杆线虫的碱性感觉。
Neuron. 2016 Jul 6;91(1):146-54. doi: 10.1016/j.neuron.2016.05.023. Epub 2016 Jun 16.
8
The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.离子型受体IR21a和IR25a介导果蝇的冷觉感知。
Elife. 2016 Apr 29;5:e13254. doi: 10.7554/eLife.13254.
9
TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway.在Duox途径的调控下，TrpA1调节食源性病原体的排便。
PLoS Genet. 2016 Jan 4;12(1):e1005773. doi: 10.1371/journal.pgen.1005773. eCollection 2016 Jan.
10
The Mosquito Repellent Citronellal Directly Potentiates Drosophila TRPA1, Facilitating Feeding Suppression.驱蚊剂香茅醛直接增强果蝇的TRPA1，促进进食抑制。
Mol Cells. 2015 Oct;38(10):911-7. doi: 10.14348/molcells.2015.0215. Epub 2015 Oct 12.