Li Xue Lian, Xie Na, Wang Song Wang, Wu Qian Hong, Ma Yan, Shu Wei, Chen Hong Mei, Zhang Li Qun, Wu Xiao Guang, Ma Li Ping, Che Nan Ying, Gao Meng Qiu
Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
Public Health Monitor and Information Service Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biomed Environ Sci. 2017 Sep;30(9):681-684. doi: 10.3967/bes2017.091.
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.
本研究旨在评估脑脊液（CSF）T-SPOT.TB检测对结核性脑膜炎（TBM）诊断的价值。对96例有明显脑膜炎症状的患者进行回顾性分析；采用T-SPOT.TB检测诊断TBM，以确定诊断敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。还绘制了受试者工作特征（ROC）曲线以评估诊断准确性。在96例纳入患者中，52例（54.2%）患者的CSF T-SPOT.TB检测敏感性、特异性、PPV和NPV分别为97.8%、78.0%、80.3%和97.5%。曲线下面积（AUC）为0.910，CSF T-SPOT.TB对TBMⅠ期、Ⅱ期和Ⅲ期患者的敏感性分别为96.7%、97.2%和98.9%。CSF T-SPOT.TB检测是一种快速准确的诊断方法，对TBM诊断具有较高的敏感性和特异性。
