Bijak M, Danek L, Smiałowski A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Pol J Pharmacol Pharm. 1988 Sep-Oct;40(5):535-41.
The effect of dopamine receptor agonists on the spontaneous bioelectrical activity of CA1 layer neurons in the hippocampal slice preparation from the Acomys and rat has been studied. The selective D1 receptor agonist SKF 38393 diminished the neuronal firing rate while the selective D2 receptor agonist LY 171555 (quinpirole) evoked an excitatory reaction, however, a great proportion of hippocampal neurons remained unresponsive to SKF 38393 and LY 171555. Both dopamine and apomorphine elicited mainly an increase in the neuronal discharge rate, the effect of the former having been antagonized by sulpiride. The present data reveal that the action of dopamine agonists on the hippocampal neurons of the Acomys generally resembles their activity on the rat hippocampal cells, however, the potency of dopamine and apomorphine in evoking the excitatory reaction is higher in the Acomys.
研究了多巴胺受体激动剂对来自非洲刺毛鼠和大鼠的海马脑片制备中CA1层神经元自发生物电活动的影响。选择性D1受体激动剂SKF 38393降低了神经元放电频率，而选择性D2受体激动剂LY 171555（喹吡罗）诱发了兴奋反应，然而，很大一部分海马神经元对SKF 38393和LY 171555无反应。多巴胺和阿扑吗啡均主要引起神经元放电频率增加，前者的作用被舒必利拮抗。目前的数据表明，多巴胺激动剂对非洲刺毛鼠海马神经元的作用总体上类似于它们对大鼠海马细胞的活性，然而，多巴胺和阿扑吗啡诱发兴奋反应的效力在非洲刺毛鼠中更高。
