Yanagisawa Mieko, Murata Hiroshi, Matsuura Masato, Fujino Yuri, Hirasawa Kazunori, Asaoka Ryo
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
Transl Vis Sci Technol. 2017 Oct 24;6(5):13. doi: 10.1167/tvst.6.5.13. eCollection 2017 Oct.
To investigate the effect of axial length (AL) on the structure-function relationship between retinal nerve fiber layer (RNFL) thickness measurements and visual field (VF) sensitivity measured with Goldmann III and V.
There were 85 eyes of 85 patients with primary open angle glaucoma included in the current study. Optical coherence tomography and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III and V targets were carried out in all patients. The optic disc and the VF were divided into six clusters and the relationship between circumpapillary RNFL (cpRNFL) thickness and VF sensitivity (with Goldmann III or V), age, and AL were investigated in each cluster.
Visual sensitivity with Goldmann III (19.3 ± 11.7 dB, mean ± standard deviation) was significantly lower than that with Goldmann V (24.6 ± 11.0 dB, < 0.001, linear mixed model). Visual sensitivities with both Goldmann III and V were significantly correlated with cpRNFL thickness in all clusters. Visual sensitivity decreased with increasing AL in the nasal retinal area for both targets, however, this phenomenon was only observed with the Goldmann V target in the temporal area.
Visual sensitivity measured with the size V target decreases with increasing AL in the temporal area, which corresponds to the papillomacular bundle. In the nasal retinal area, visual sensitivity decreases with the increase of AL for both Goldmann III and Goldmann V.
Careful consideration is needed when measuring visual sensitivity using Goldmann V target in glaucomatous eyes with increased AL.
研究眼轴长度（AL）对视网膜神经纤维层（RNFL）厚度测量值与使用戈德曼Ⅲ和Ⅴ型视野计（VF）测量的视野敏感度之间结构 - 功能关系的影响。
本研究纳入了85例原发性开角型青光眼患者的85只眼。对所有患者进行了光学相干断层扫描以及使用戈德曼Ⅲ和Ⅴ型视标进行的视野检查（Humphrey视野分析仪24 - 2或30 - 2）。将视盘和视野分为六个簇，并在每个簇中研究视乳头周围RNFL（cpRNFL）厚度与视野敏感度（使用戈德曼Ⅲ或Ⅴ型视标）、年龄和眼轴长度之间的关系。
使用戈德曼Ⅲ型视标时的视野敏感度（19.3±11.7dB，平均值±标准差）显著低于使用戈德曼Ⅴ型视标时的视野敏感度（24.6±11.0dB，<0.001，线性混合模型）。在所有簇中，使用戈德曼Ⅲ和Ⅴ型视标时的视野敏感度均与cpRNFL厚度显著相关。对于两个视标，在鼻侧视网膜区域，视野敏感度均随眼轴长度增加而降低，然而，这种现象仅在颞侧区域使用戈德曼Ⅴ型视标时观察到。
使用Ⅴ型视标测量的视野敏感度在颞侧区域随眼轴长度增加而降低，该区域对应于视乳头黄斑束。在鼻侧视网膜区域，使用戈德曼Ⅲ和戈德曼Ⅴ型视标时，视野敏感度均随眼轴长度增加而降低。
在眼轴长度增加的青光眼眼中使用戈德曼Ⅴ型视标测量视野敏感度时需要仔细考虑。
