Oli J M, Osefo N J, Okeke I C
Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Int J Fertil. 1986 Mar-Apr;31(1):50-5.
The parity and the perinatal mortality of 226 married Nigerian female diabetics, aged 20 to 76 years (mean 47.1 years), and 226 married female nondiabetics matched for age and educational level with the diabetics were studied. There was no statistically significant difference between the diabetics and nondiabetics in terms of primary infertility, irrespective of age of onset of diabetes. In the group with one to four deliveries, the nondiabetics significantly outnumbered the diabetics (P less than 0.001) irrespective of age of onset of diabetes. In the group with seven to nine deliveries, only the diabetics of child-bearing age (P less than 0.01); and in the group with 10 or more deliveries, diabetics significantly outnumbered the nondiabetics irrespective of age of onset of diabetes (P less than 0.01). There was a statistically significant difference between the diabetics and nondiabetics in terms of the overall perinatal mortality (P less than 0.001). However, this difference was not significant in diabetics of childbearing age. In Nigeria, where large families are common and children often born in rapid succession, high parity appears not only to increase the chances of a woman developing diabetes in late life but also in early life. Effective birth control practice may thus help in reducing the incidence of diabetes amongst Nigerian women. Additionally, a programme extending to the rural areas aimed at early detection of diabetes and proper management of the pregnant diabetic by a team of medical personnel with special interest in diabetes will help in reducing the perinatal mortality in Nigerian diabetics.
对226名年龄在20至76岁(平均47.1岁)的已婚尼日利亚女性糖尿病患者以及226名在年龄和教育水平上与糖尿病患者相匹配的已婚非糖尿病女性的产次和围产期死亡率进行了研究。无论糖尿病发病年龄如何,糖尿病患者和非糖尿病患者在原发性不孕方面无统计学显著差异。在有1至4次分娩的组中,无论糖尿病发病年龄如何,非糖尿病患者的人数均显著多于糖尿病患者(P<0.001)。在有7至9次分娩的组中,只有育龄期糖尿病患者(P<0.01);而在有10次或更多次分娩的组中,无论糖尿病发病年龄如何,糖尿病患者的人数均显著多于非糖尿病患者(P<0.01)。糖尿病患者和非糖尿病患者在总体围产期死亡率方面存在统计学显著差异(P<0.001)。然而,这种差异在育龄期糖尿病患者中并不显著。在尼日利亚,大家庭很常见,孩子往往接连出生,高生育次数似乎不仅会增加女性晚年患糖尿病的几率,也会增加早年患糖尿病的几率。因此,有效的节育措施可能有助于降低尼日利亚女性糖尿病的发病率。此外,如果开展一项延伸至农村地区的项目,由一组对糖尿病有特殊兴趣的医务人员对糖尿病进行早期检测并对妊娠糖尿病患者进行妥善管理,将有助于降低尼日利亚糖尿病患者的围产期死亡率。