儿童和青少年自身免疫性多腺体综合征的特点
Peculiarities of autoimmune polyglandular syndromes in children and adolescents.
作者信息
Zirilli Giuseppina, Santucci Simona, Cuzzupè Chiara, Corica Domenico, Pitrolo Elda, Salzano Giuseppina
机构信息
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
出版信息
Acta Biomed. 2017 Oct 23;88(3):271-275. doi: 10.23750/abm.v88i3.5898.
Abstract
BACKGROUND
no reviews have specifically addressed , to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric ageObjectives: to review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescenceDesign: the main features of the different APSs in pediatric age were compared among them.
CONCLUSIONS
- Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparathyroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications.
摘要
背景
迄今为止，尚无综述专门探讨自身免疫性多腺体综合征（APSs）在儿童期是否具有独特的流行病学特征和表型表现。
目的
回顾关于儿童期和青少年期APSs的特定流行病学和临床特征的最新文献数据。
设计
比较了不同APSs在儿童期的主要特征。
结论
1）在不同的APSs中，儿童期最典型的是APS-1；2）APS-1不仅以经典三联征（慢性念珠菌病-肾上腺皮质功能减退-甲状旁腺功能减退）为特征，且其临床谱随时间不断扩大；3）根据两种不同的疾病分类，APS-2可能具有不同的流行病学和临床表型。
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