Bruinse H W, Vermeulen-Meiners C, Wit J M
Department Obstetrics/Gynecology, University Hospital, Utrecht, The Netherlands.
Fetal Ther. 1988;3(3):152-7. doi: 10.1159/000263347.
Euthyroid or even hypothyroid pregnant women without antithyroid medication but with a history of treatment for thyrotoxicosis, almost always a subtotal strumectomy, may still produce thyroid-stimulating immunoglobulins. This can induce fetal and neonatal thyrotoxicosis. Without treatment this results in a high fetal and neonatal mortality and morbidity. Fetal treatment by administering antithyroid drugs during pregnancy improves this prognosis remarkably. A case is described, the literature is reviewed and guidelines for diagnosis and treatment are presented.
甲状腺功能正常甚至甲状腺功能减退的孕妇，未服用抗甲状腺药物，但有甲状腺毒症治疗史（几乎均为甲状腺次全切除术），仍可能产生促甲状腺素受体抗体。这可诱发胎儿及新生儿甲状腺毒症。若不治疗，会导致高胎儿及新生儿死亡率和发病率。孕期给予抗甲状腺药物进行胎儿治疗可显著改善这种预后。本文描述了1例病例，回顾了相关文献并提出了诊断和治疗指南。
