Kokai Y, Wada T, Myers J N, Brown V I, Dobashi K, Cohen J, Hamuro J, Weiner D B, Greene M I
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104-6082.
Princess Takamatsu Symp. 1988;19:45-57.
p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.
p185neu是neu基因的蛋白质产物，是一种酪氨酸激酶受体，与表皮生长因子（EGF）受体在结构上相似。p185neu受体的同源配体仍然未知。我们已经明确了：1）neu基因产物在发育组织中的阶段和组织特异性表达模式；2）p185neu的磷酸化以及EGF对p185neu酪氨酸激酶活性的调节；3）细胞大鼠p185neu与EGF受体的协同相互作用导致细胞转化；4）正常和致癌p185neu的结构和功能差异。这些观察结果解释了p185neu如何参与正常发育和肿瘤转化的一些特征。
