Wasserman Deena D., Thurman Jeff, Healy Megan
Temple University Hospital
University of Louisville/Norton Healthcare
Hyperthermia is defined as a body temperature greater than 40 degrees C. Several conditions can cause hyperthermia. In sepsis, the immunologic reaction to the infection most often manifests as a fever. Some toxic ingestions and withdrawal states can cause elevated body temperature. Certain medications can cause a hyperthermic response, such as in neuroleptic malignant syndrome. The most common disease that can be treated by cooling alone is heat-related illness and heat stroke. Heat-related illness is a spectrum of disease that occurs when the body's thermoregulatory system does not work properly. Heat exhaustion is characterized by elevated core body temperature associated with orthostatic hypotension, tachycardia, diaphoresis, and tachypnea. Heat stroke is defined as elevated core body temperature plus central nervous system involvement (delirium, decreased the level of consciousness, or ataxia). Heat-related illness most often affects athletes (exertional hyperthermia), but can also occur during the warm weather months or in locations with extreme temperatures. Patients with impaired thermoregulation (those at extremes of age, the obese or mentally ill) are at higher risk. The definitive treatment for heat-related illness is total body cooling. Conduction and evaporation are the two modes of cooling employed in the treatment of heat-related illness. Studies have shown ice water immersion to be the most effective and most rapid. However, there are obvious barriers to performing this in an emergency department. Marathons and other athletic events that have frequent heat-related illness sometimes have this capability. Evaporation (mist and fan) is the second most rapid way to cool a patient. Ice packs to the groin, axilla, neck, and areas near other great vessels have been shown to be less effective. Cooled intravenous fluids have been studied, but there is no clear consensus regarding their benefit (preservation of neurologic function) versus potential harm (induced shivering), but they may be considered. This article will discuss the procedure for performing evaporative cooling with other adjuncts in the field. The priority in heat-related illness is early recognition and intervention. Military and sports literature has identified 40 degrees C as the target, and the faster the target is achieved, the lower the patient mortality.
体温过高定义为体温高于40摄氏度。多种情况可导致体温过高。在脓毒症中,对感染的免疫反应最常表现为发热。一些有毒物质摄入和戒断状态可导致体温升高。某些药物可引起体温过高反应,如在抗精神病药恶性综合征中。仅通过降温就能治疗的最常见疾病是与热相关的疾病和热射病。与热相关的疾病是一系列疾病,当人体的体温调节系统不能正常工作时就会发生。热衰竭的特征是核心体温升高,伴有直立性低血压、心动过速、出汗和呼吸急促。热射病定义为核心体温升高加中枢神经系统受累(谵妄、意识水平下降或共济失调)。与热相关的疾病最常影响运动员(劳力性体温过高),但也可在温暖的天气月份或极端温度的地区发生。体温调节受损的患者(年龄极端者、肥胖者或精神疾病患者)风险更高。与热相关疾病的确定性治疗是全身降温。传导和蒸发是治疗与热相关疾病时采用的两种降温方式。研究表明,冰水浸泡是最有效、最快速的。然而,在急诊科进行这种操作存在明显障碍。马拉松和其他经常出现与热相关疾病的体育赛事有时具备这种能力。蒸发(喷雾和风扇)是给患者降温的第二快方法。腹股沟、腋窝、颈部和其他大血管附近区域使用冰袋已被证明效果较差。已对冷却的静脉输液进行了研究,但关于其益处(保护神经功能)与潜在危害(诱发寒战)尚无明确共识,但可考虑使用。本文将讨论在现场使用其他辅助手段进行蒸发冷却的操作步骤。与热相关疾病的首要任务是早期识别和干预。军事和体育文献已将40摄氏度确定为目标,达到目标的速度越快,患者死亡率越低。