Ose Keiko, Miyamoto Mitsugu, Fujisawa Takuo, Katagi Toshiyuki
Environmental Health Science Laboratory, Sumitomo Chemical Company, Limited , 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-8555, Japan.
Environmental Health Science Laboratory, Sumitomo Chemical Company, Limited , 3-1-98 Kasugade-naka, Konohana-ku, Osaka-city, Osaka 554-8558, Japan.
J Agric Food Chem. 2017 Nov 22;65(46):9980-9986. doi: 10.1021/acs.jafc.7b04184. Epub 2017 Nov 8.
Bioconcentration and metabolism of pyriproxyfen uniformly labeled with C at the phenoxyphenyl ring were studied using tadpoles of African clawed frog, Xenopus laevis, exposed to water at the nominal concentrations of 3 and 300 ppb for 22 days under the flow-through conditions, with a following 3 day depuration phase. Neither meaningful mortality nor abnormal behavior was observed in control and exposure groups throughout the study. After the rapid uptake to tadpoles, pyriproxyfen was extensively metabolized and excreted, and as a result, steady-state bioconcentration factors and depuration half-lives ranged from 550 to 610 and from 0.34 to 0.54 days, respectively. The metabolites were mostly distributed in the liver or gastrointestinal tract. The major metabolic reactions were hydroxylation at the 4' position of the phenoxyphenyl group and cleavage of the ether linkage, followed by sulfate conjugation.
使用非洲爪蟾（Xenopus laevis）蝌蚪，在流动条件下，以3 ppb和300 ppb的标称浓度暴露于水中22天，随后进行3天的净化阶段，研究了在苯氧基苯基环上均匀标记有C的吡丙醚的生物富集和代谢情况。在整个研究过程中，对照组和暴露组均未观察到有意义的死亡率或异常行为。吡丙醚迅速被蝌蚪摄取后，被广泛代谢和排泄，结果，稳态生物富集因子和净化半衰期分别为550至610和0.34至0.54天。代谢产物大多分布在肝脏或胃肠道中。主要的代谢反应是苯氧基苯基的4'位羟基化和醚键断裂，随后是硫酸结合。
