炎症相关基因多态性与复发性流产之间的关联。
The association between polymorphisms of genes related to inflammation and recurrent pregnancy loss.
作者信息
Gu Yan, Wang Jian Mei, Zhang Zhao Feng, Wang Jian, Cao Yun Lei, Pan Cai Jun, Yin Li Rong, Du Jing
机构信息
a The Second Hospital of Tianjin Medical University , Tianjin , China.
b Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD , Fudan University , Shanghai , China.
出版信息
Gynecol Endocrinol. 2018 Apr;34(4):349-352. doi: 10.1080/09513590.2017.1395837. Epub 2017 Oct 31.
AIM
Recurrent pregnancy loss (RPL) occurs in 1-2% of pregnant women and about 50% of RPL cases are unexplained. Previous studies have shown that genetic variation in immune response genes can contribute to the risk in pregnancy maintenance during pregnancy. The aim of the present study was to evaluate the relationship between RPL and genes those have previously been associated with an inflammatory process on 107 RPL cases and 187 healthy controls.
METHODS
In this work, the single-nucleotide polymorphisms was examined by utilizing the direct sequencing and the Sequenom MassARRAY system.
RESULTS
The FAU rs769440 G allele had higher frequencies in patients with RPL (p = .019). No association was observed between other polymorphisms and RPL.
CONCLUSION
The results showed an association between FAU rs769440 polymorphism and RPL in Chinese Han population.
目的
复发性流产（RPL）发生于1%-2%的孕妇中，约50%的RPL病例病因不明。既往研究表明，免疫反应基因的遗传变异可能会增加孕期维持妊娠的风险。本研究的目的是评估107例RPL病例和187例健康对照中RPL与先前已与炎症过程相关的基因之间的关系。
方法
在本研究中，利用直接测序和Sequenom MassARRAY系统检测单核苷酸多态性。
结果
FAU rs769440 G等位基因在RPL患者中的频率较高（p = 0.019）。未观察到其他多态性与RPL之间存在关联。
结论
结果表明，在中国汉族人群中，FAU rs769440多态性与RPL之间存在关联。
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