孕激素受体基因多态性（+331G/a）与乳腺癌风险之间无关联：一项更新的荟萃分析。
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis.
作者信息
Qi Xing-Ling, Yao Jun, Zhang Yong
机构信息
Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, People's Republic of China.
School of Forensic Medicine, China Medical University, Shenyang, 110122, People's Republic of China.
出版信息
BMC Med Genet. 2017 Oct 30;18(1):123. doi: 10.1186/s12881-017-0487-3.
BACKGROUND
Many published studies have estimated the association between the +331G/A (rs10895068) polymorphism in the progesterone receptor (PgR) gene and breast cancer risk. However, the results remain inconsistent and controversial. To address this inconsistency, we systematically interrogated the aforementioned association via a meta-analysis.
METHODS
Through a literature search, we identified 13 case-control studies, including 12,453 cases and 14,056 case-free controls. The strengths of reported associations were evaluated using odds ratios (ORs) with 95% confidence intervals (95%CIs).
RESULTS
An association was found between +331G/A polymorphism and +331G/A risk in the dominant model (p = 0.027). Via subgroup analysis, we found no association between +331G/A and breast cancer risk in Caucasians, Asians or mixed racial groups.
CONCLUSIONS
Through meta-analysis, we were able to gain insight into previously reported associations between +331G/A polymorphism and breast cancer risk. However, further studies are still needed to provide more evidence.
背景
许多已发表的研究估计了孕激素受体（PgR）基因中+331G/A（rs10895068）多态性与乳腺癌风险之间的关联。然而，结果仍然不一致且存在争议。为了解决这种不一致性，我们通过荟萃分析系统地探究了上述关联。
方法
通过文献检索，我们确定了13项病例对照研究，包括12453例病例和14056例无病例对照。使用比值比（OR）和95%置信区间（95%CI）评估报告关联的强度。
结果
在显性模型中发现+331G/A多态性与+331G/A风险之间存在关联（p = 0.027）。通过亚组分析，我们发现在白种人、亚洲人或混合种族群体中，+331G/A与乳腺癌风险之间无关联。
结论
通过荟萃分析，我们能够深入了解先前报道的+331G/A多态性与乳腺癌风险之间的关联。然而，仍需要进一步的研究来提供更多证据。
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