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基于兰姆波法的软骨-骨结构弹性测量中的近场效应。

Near field effect on elasticity measurement for cartilage-bone structure using Lamb wave method.

机构信息

Orthopaedic Institute, Department of Orthopaedics, the First Affiliated Hospital, Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.

Department of Radiology, Mayo Clinic, Rochester, MN, United States of America.

出版信息

Biomed Eng Online. 2017 Oct 30;16(1):123. doi: 10.1186/s12938-017-0417-9.

Abstract

BACKGROUND

Cartilage elasticity changes with cartilage degeneration. Hence, cartilage elasticity detection might be an alternative to traditional imaging methods for the early diagnosis of osteoarthritis. Based on the wave propagation measurement, Shear wave elastography (SWE) become an emerging non-invasive elasticity detection method. The wave propagation model, which is affected by tissue shapes, is crucial for elasticity estimating in SWE. However, wave propagation model for cartilage was unclear.

METHODS

This study aimed to establish a wave propagation model for the cartilage-bone structure. We fabricated a cartilage-bone structure, and studied the elasticity measurement and wave propagation by experimental and numerical Lamb wave method (LWM).

RESULTS

Results indicated the wave propagation model satisfied the lamb wave theory for two-layered structure. Moreover, a near field region, which affects wave speed measurements and whose occurrence can be prevented if the wave frequency is larger than one critical frequency, was observed.

CONCLUSION

Our findings would provide a theoretical foundation for further application of LWM in elasticity measurement of cartilage in vivo. It can help the application of LWM to the diagnosis of osteoarthritis.

摘要

背景

软骨弹性随软骨退变而改变。因此,软骨弹性检测可能是传统影像学方法在骨关节炎早期诊断中的替代方法。基于波传播测量,剪切波弹性成像(SWE)成为一种新兴的无创弹性检测方法。波传播模型受组织形状影响,对于 SWE 中的弹性估计至关重要。然而,软骨的波传播模型尚不清楚。

方法

本研究旨在建立软骨-骨结构的波传播模型。我们制作了一个软骨-骨结构,并通过实验和数值兰姆波方法(LWM)研究了弹性测量和波传播。

结果

结果表明,波传播模型满足两层结构的兰姆波理论。此外,观察到一个近场区域,该区域会影响波速测量,如果波频率大于一个临界频率,则可以防止该区域的发生。

结论

我们的发现将为进一步将 LWM 应用于体内软骨弹性测量提供理论基础。它可以帮助 LWM 应用于骨关节炎的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/5663048/009f3c45c4cd/12938_2017_417_Fig1_HTML.jpg

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