FitzGerald D J, Willingham M C, Pastan I
Cancer Treat Res. 1988;37:161-73. doi: 10.1007/978-1-4613-1083-9_11.
Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT. Deletion analysis of the structural gene of PE has helped assign specific functions to different portions of the molecule. Current efforts are focused on making ITs with recombinant PE.
单克隆抗体可与藻红蛋白（PE）偶联制成非常有效的免疫毒素。其中两种免疫毒素（PE-HB21和OVB-3-PE）已在卵巢癌裸鼠模型中显示出抗肿瘤活性。PE免疫毒素的活性比相应的蓖麻毒素A链免疫毒素至少高10倍。对PE结构基因的缺失分析有助于确定该分子不同部分的特定功能。目前的工作重点是用重组PE制备免疫毒素。
