Takamura Tomohiro, Hori Masaaki, Kamagata Koji, Kumamaru Kanako K, Irie Ryusuke, Hagiwara Akifumi, Hamasaki Nozomi, Aoki Shigeki
Department of Radiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Jpn J Radiol. 2018 Jan;36(1):40-50. doi: 10.1007/s11604-017-0695-y. Epub 2017 Oct 31.
To assess the influence of high temporal resolution on the perfusion measurements and image quality of perfusion maps, by applying simultaneous-multi-slice acquisition (SMS) dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI).
DSC-MRI data using SMS gradient-echo echo planar imaging sequences in 10 subjects with no intracranial abnormalities were retrospectively analyzed. Three additional data sets with temporal resolution of 1.0, 1.5, and 2.0 s were created from the raw data sets of 0.5 s. Cerebral blood flow (CBF), cerebral blood volume, mean transit time (MTT), time to peak (TTP), and time to maximum tissue residue function (T ) measurements were performed, as was visual perfusion map analysis. The perfusion parameter for temporal resolution of 0.5 s (reference) was compared with each synthesized perfusion parameter.
CBF, MTT, and TTP values at temporal resolutions of 1.5 and 2.0 s differed significantly from the reference. The image quality of MTT, TTP, and T maps deteriorated with decreasing temporal resolution.
The temporal resolution of DSC-MRI influences perfusion parameters and SMS DSC-MRI provides better image quality for MTT, TTP, and T maps.
通过应用同时多层采集（SMS）动态磁敏感对比增强（DSC）磁共振成像（MRI），评估高时间分辨率对灌注测量及灌注图图像质量的影响。
回顾性分析10例无颅内异常受试者使用SMS梯度回波平面成像序列的DSC-MRI数据。从0.5秒的原始数据集中创建另外三个时间分辨率分别为1.0、1.5和2.0秒的数据集。进行脑血流量（CBF）、脑血容量、平均通过时间（MTT）、达峰时间（TTP）和最大组织残留函数时间（T）测量，并进行视觉灌注图分析。将0.5秒时间分辨率（参考值）的灌注参数与每个合成的灌注参数进行比较。
1.5秒和2.0秒时间分辨率下的CBF、MTT和TTP值与参考值有显著差异。MTT、TTP和T图的图像质量随时间分辨率降低而变差。
DSC-MRI的时间分辨率影响灌注参数，且SMS DSC-MRI为MTT、TTP和T图提供了更好的图像质量。
