微小RNA和假基因在癌症中的作用
Involvement of miRNAs and Pseudogenes in Cancer.
作者信息
Tutar Lütfi, Özgür Aykut, Tutar Yusuf
机构信息
Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Ahi Evran University, Kırşehir, Turkey.
Division of Biochemistry, Department of Basic Sciences, Faculty of Pharmacy, Cumhuriyet University, 58140, Sivas, Turkey.
出版信息
Methods Mol Biol. 2018;1699:45-66. doi: 10.1007/978-1-4939-7435-1_3.
Our understanding of cancer pathways has been changed by the determination of noncoding transcripts in the human genome in recent years. miRNAs and pseudogenes are key players of the noncoding transcripts from the genome, and alteration of their expression levels provides clues for significant biomarkers in pathogenesis of diseases. Especially, miRNAs and pseudogenes have both oncogenic and tumor-suppressive roles in each step of cancer tumorigenesis. In this current study, association between oncogenes and miRNAs-pseudogenes was reviewed and determined in human cancer by the CellMiner web-tool.
近年来，人类基因组中非编码转录本的确定改变了我们对癌症通路的理解。微小RNA（miRNAs）和假基因是基因组中非编码转录本的关键参与者，它们表达水平的改变为疾病发病机制中的重要生物标志物提供了线索。特别是，miRNAs和假基因在癌症肿瘤发生的每个步骤中都具有致癌和抑癌作用。在本研究中，通过CellMiner网络工具对人类癌症中癌基因与miRNAs-假基因之间的关联进行了综述和确定。
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