Sarmah Nipon, Revathi D, Sheelu G, Yamuna Rani K, Sridhar S, Mehtab V, Sumana C
Chemical Engineering Div., CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Academy of Scientific and Innovative Research (AcSIR), Chennai, 600 113, India.
Biotechnol Prog. 2018 Jan;34(1):5-28. doi: 10.1002/btpr.2581. Epub 2017 Dec 4.
Lipases are the industrially important biocatalysts, which are envisioned to have tremendous applications in the manufacture of a wide range of products. Their unique properties such as better stability, selectivity and substrate specificity position them as the most expansively used industrial enzymes. The research on production and applications of lipases is ever growing and there exists a need to have a latest review on the research findings of lipases. The present review aims at giving the latest and broadest overall picture of research and development on lipases by including the current studies and progressions not only in the diverse industrial application fields of lipases, but also with regard to its structure, classification and sources. Also, a special emphasis has been made on the aspects such as process optimization, modeling, and design that are very critical for further scale-up and industrial implementation. The detailed tabulations provided in each section, which are prepared by the exhaustive review of current literature covering the various aspects of lipase including its production and applications along with example case studies, will serve as the comprehensive source of current advancements in lipase research. This review will be very useful for the researchers from both industry as well as academia in promoting lipolysis as the most promising approaches to intensified, greener and sustainable processes. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:5-28, 2018.
脂肪酶是具有重要工业价值的生物催化剂，有望在多种产品的制造中得到广泛应用。它们具有独特的性质，如更好的稳定性、选择性和底物特异性，这使其成为应用最为广泛的工业酶。脂肪酶生产与应用的研究不断发展，因此有必要对脂肪酶的研究成果进行最新综述。本综述旨在通过纳入脂肪酶在不同工业应用领域的当前研究和进展，以及其结构、分类和来源等方面的内容，呈现脂肪酶研发的最新、最全面的整体情况。此外，还特别强调了工艺优化、建模和设计等对进一步扩大规模和工业实施至关重要的方面。各章节提供的详细表格是通过对涵盖脂肪酶各个方面（包括其生产和应用以及实例研究）的当前文献进行详尽综述编制而成的，将作为脂肪酶研究当前进展的综合来源。本综述对于来自工业界和学术界的研究人员推动脂肪酶解成为强化、绿色和可持续工艺最具前景的方法将非常有用。© 2017美国化学工程师学会生物技术进展，34:5 - 28，2018。
