Patel Shardool, Carmichael Jan M, Taylor Janice M, Bounthavong Mark, Higgins Diana T
1 VHA Sierra Pacific Network (VISN 21), Reno, NV, USA.
2 VHA Pharmacy Benefits Management, San Diego, CA, USA.
Ann Pharmacother. 2018 Apr;52(4):325-331. doi: 10.1177/1060028017739388. Epub 2017 Oct 31.
Chronic opioid therapy-clinical reminder (COT-CR) is a decision support tool to prompt providers to carefully assess patients prescribed chronic opioids. This tool was developed to address inappropriate opioid prescribing.
To determine COT-CR's impact on reducing morphine equivalent monthly dose (MEMD) and risk index for overdose or serious prescription opioid-induced respiratory depression (RIOSORD) values in veterans receiving chronic opioids.
This retrospective cohort review matched patients with a complete COT-CR to patients with an incomplete COT-CR using propensity scores. In the primary aim, an interrupted time series design evaluated for changes in MEMD 12 months before and 6 months after the index date. The index date was the first pain or primary care provider visit post COT-CR installation. In the secondary aims, a retrospective cohort design was used to evaluate the changes in RIOSORD index score and risk class 6 months after the index date.
After matching, 3801 patients were included in the complete and incomplete COT-CR groups, respectively. Greater average reduction in MEMD (-11.6 MEMD; 95% CI = -0.97 to -22.25 MEMD; P = 0.032) and RIOSORD index score (-0.53 RIOSORD index score; 95% CI = -1.00, -0.05 RIOSORD index score; P = 0.030) was observed in patients with a complete COT-CR compared to patients with an incomplete COT-CR. Differences in RIOSORD risk class were insignificant.
Completing the COT-CR was associated with reduced MEMD and RIOSORD values. This suggests that active monitoring can change prescribing patterns, thereby, reducing the overall risk of opioid overdose in at-risk veterans.
慢性阿片类药物治疗临床提醒(COT-CR)是一种决策支持工具,旨在促使医疗服务提供者仔细评估开具慢性阿片类药物处方的患者。该工具的开发是为了解决阿片类药物的不适当处方问题。
确定COT-CR对接受慢性阿片类药物治疗的退伍军人降低每月吗啡当量剂量(MEMD)以及过量或严重处方阿片类药物引起的呼吸抑制风险指数(RIOSORD)值的影响。
本回顾性队列研究使用倾向评分将COT-CR完整的患者与COT-CR不完整的患者进行匹配。在主要目标中,采用中断时间序列设计评估索引日期前12个月和索引日期后6个月MEMD的变化。索引日期是安装COT-CR后首次就诊疼痛科或初级保健科的日期。在次要目标中,采用回顾性队列设计评估索引日期后6个月RIOSORD指数评分和风险等级的变化。
匹配后,完整和不完整COT-CR组分别纳入3801例患者。与COT-CR不完整的患者相比,COT-CR完整的患者在MEMD(-11.6 MEMD;95%CI=-0.97至-22.25 MEMD;P=0.032)和RIOSORD指数评分(-0.53 RIOSORD指数评分;95%CI=-1.00,-0.05 RIOSORD指数评分;P=0.030)方面的平均降低幅度更大。RIOSORD风险等级差异不显著。
完成COT-CR与降低MEMD和RIOSORD值相关。这表明主动监测可以改变处方模式,从而降低高危退伍军人阿片类药物过量的总体风险。