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评估临床决策支持工具对减少退伍军人慢性阿片类药物剂量及降低风险分级的影响。

Evaluating the Impact of a Clinical Decision Support Tool to Reduce Chronic Opioid Dose and Decrease Risk Classification in a Veteran Population.

作者信息

Patel Shardool, Carmichael Jan M, Taylor Janice M, Bounthavong Mark, Higgins Diana T

机构信息

1 VHA Sierra Pacific Network (VISN 21), Reno, NV, USA.

2 VHA Pharmacy Benefits Management, San Diego, CA, USA.

出版信息

Ann Pharmacother. 2018 Apr;52(4):325-331. doi: 10.1177/1060028017739388. Epub 2017 Oct 31.

Abstract

BACKGROUND

Chronic opioid therapy-clinical reminder (COT-CR) is a decision support tool to prompt providers to carefully assess patients prescribed chronic opioids. This tool was developed to address inappropriate opioid prescribing.

OBJECTIVE

To determine COT-CR's impact on reducing morphine equivalent monthly dose (MEMD) and risk index for overdose or serious prescription opioid-induced respiratory depression (RIOSORD) values in veterans receiving chronic opioids.

METHODS

This retrospective cohort review matched patients with a complete COT-CR to patients with an incomplete COT-CR using propensity scores. In the primary aim, an interrupted time series design evaluated for changes in MEMD 12 months before and 6 months after the index date. The index date was the first pain or primary care provider visit post COT-CR installation. In the secondary aims, a retrospective cohort design was used to evaluate the changes in RIOSORD index score and risk class 6 months after the index date.

RESULTS

After matching, 3801 patients were included in the complete and incomplete COT-CR groups, respectively. Greater average reduction in MEMD (-11.6 MEMD; 95% CI = -0.97 to -22.25 MEMD; P = 0.032) and RIOSORD index score (-0.53 RIOSORD index score; 95% CI = -1.00, -0.05 RIOSORD index score; P = 0.030) was observed in patients with a complete COT-CR compared to patients with an incomplete COT-CR. Differences in RIOSORD risk class were insignificant.

CONCLUSION

Completing the COT-CR was associated with reduced MEMD and RIOSORD values. This suggests that active monitoring can change prescribing patterns, thereby, reducing the overall risk of opioid overdose in at-risk veterans.

摘要

背景

慢性阿片类药物治疗临床提醒(COT-CR)是一种决策支持工具,旨在促使医疗服务提供者仔细评估开具慢性阿片类药物处方的患者。该工具的开发是为了解决阿片类药物的不适当处方问题。

目的

确定COT-CR对接受慢性阿片类药物治疗的退伍军人降低每月吗啡当量剂量(MEMD)以及过量或严重处方阿片类药物引起的呼吸抑制风险指数(RIOSORD)值的影响。

方法

本回顾性队列研究使用倾向评分将COT-CR完整的患者与COT-CR不完整的患者进行匹配。在主要目标中,采用中断时间序列设计评估索引日期前12个月和索引日期后6个月MEMD的变化。索引日期是安装COT-CR后首次就诊疼痛科或初级保健科的日期。在次要目标中,采用回顾性队列设计评估索引日期后6个月RIOSORD指数评分和风险等级的变化。

结果

匹配后,完整和不完整COT-CR组分别纳入3801例患者。与COT-CR不完整的患者相比,COT-CR完整的患者在MEMD(-11.6 MEMD;95%CI=-0.97至-22.25 MEMD;P=0.032)和RIOSORD指数评分(-0.53 RIOSORD指数评分;95%CI=-1.00,-0.05 RIOSORD指数评分;P=0.030)方面的平均降低幅度更大。RIOSORD风险等级差异不显著。

结论

完成COT-CR与降低MEMD和RIOSORD值相关。这表明主动监测可以改变处方模式,从而降低高危退伍军人阿片类药物过量的总体风险。

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