根据 CaProMat 研究中肺癌表型，职业接触石棉和结晶硅的流行情况：一项仅病例研究。
Prevalence of occupational exposure to asbestos and crystalline silica according to phenotypes of lung cancer from the CaProMat study: A case-only study.
机构信息
University of Bordeaux, ISPED, INSERM U1219-Bordeaux Population Heath Center INSERM U1219, EPICENE, Bordeaux, France.
INSERM, ISPED, U1219-Bordeaux Population Heath Center U1219, EPICENE, Bordeaux, France.
出版信息
Am J Ind Med. 2018 Jan;61(1):85-99. doi: 10.1002/ajim.22765. Epub 2017 Oct 31.
BACKGROUND
The objective of the study was to compare the prevalence of occupational exposure to asbestos and crystalline silica according to histological types of lung cancer and age at diagnosis.
METHODS
CaProMat study is a pooled case-only study conducted between 1996 and 2011. The current study consisted of 6521 lung cancer cases. Occupational exposure to asbestos and crystalline silica was assessed by two Job-Exposure Matrices. A weighted prevalence of exposure was derived and compared according to histological types and age at diagnosis.
RESULTS
There was no difference of weighted prevalence of exposure to asbestos and crystalline silica according to histological types of lung cancer. There was a statistically significant difference of weighted prevalence of exposure to asbestos and crystalline silica according to age at diagnosis.
CONCLUSIONS
Due to the limited clinical importance of the difference, neither the histological type, nor the age at diagnosis can be used as an indicator for the occupational exposure to asbestos or crystalline silica.
背景
本研究旨在比较不同肺癌组织学类型和诊断时年龄与石棉及结晶二氧化硅职业暴露的患病率。
方法
CaProMat 研究是一项在 1996 年至 2011 年间进行的病例对照巢式研究。本研究纳入了 6521 例肺癌病例。通过两个职业暴露矩阵评估石棉和结晶二氧化硅的职业暴露情况。根据组织学类型和诊断时年龄得出加权暴露率，并进行比较。
结果
石棉和结晶二氧化硅的加权暴露率与肺癌的组织学类型无差异。石棉和结晶二氧化硅的加权暴露率与诊断时年龄存在统计学差异。
结论
由于差异的临床重要性有限，组织学类型和诊断时年龄均不能作为石棉或结晶二氧化硅职业暴露的指标。
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