, a microtubule-associated protein, promotes tumor growth and progression of human gastric cancer.

, a microtubule-associated protein (MAP), is overexpressed in diverse types of human cancer. The expression and critical role of in human gastric cancer (GC), however, remains largely unknown. Here, we conducted molecular, cellular and clinical analyses to evaluate the functional link of to GC. expression was elevated in gastric tumors, and its expression strongly correlated with lymph node metastasis and TNM stage. In addition, over-expression of in GC cell lines enhanced cell proliferation, cycle progression, migration, invasion, as well as tumor growth and metastatic dissemination . Furthermore, exhibited a strong cell cycle correlated expression. The knockdown of inhibited the regrowth of microtubules in GC cells. FAM83D was co-immunoprecipitated with HMMR, TPX2, and AURKA, a set of drivers of mitosis progression. Taken together, our results demonstrate as an important player in the development of human gastric cancer, and as a potential therapeutic target for the treatment of cancer.