• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肿瘤浸润性FoxP3调节性T细胞预测结直肠癌患者的良好预后：一项荟萃分析。

Tumor-infiltrating FoxP3 Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis.

作者信息

Hu Guoming, Li Zhi'an, Wang Shimin

机构信息

Department of General Surgery (Breast and Thyroid Surgery), Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Shaoxing, China.

Department of Surgical Oncology, Shaoxing Second Hospital, 312000, Shaoxing, China.

出版信息

Oncotarget. 2017 Jun 7;8(43):75361-75371. doi: 10.18632/oncotarget.17722. eCollection 2017 Sep 26.

DOI:10.18632/oncotarget.17722
PMID:29088871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5650426/
Abstract

FoxP3 regulatory T cells (FoxP3 Tregs) are considered to be a key mediator in immune escape and tumor progression. However, the role of FoxP3 Tregs in human colorectal cancer (CRC) remains controversial. Herein, we conducted a meta-analysis including 17 published studies with 3811 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating FoxP3 Tregs in human CRC. We found FoxP3 Tregs infiltrating into both intraepithelium and stroma within tumor were significantly positively correlated with 1, 3, 5 and 10-year overall survival (OS), but not with 1, 3, 5-year disease-free survival (DFS) of patients. Interestingly, in stratified analyses by compartments within tumor FoxP3 Tregs infiltrating into, FoxP3 Tregs invading stromal compartment significantly improved 3 and 5-year OS, yet OS wasn't improved when FoxP3 Tregs infiltrated into intraepithelium only. Furthermore, FoxP3 Tregs invading both intraepithelium and stroma significantly inversely correlated with TNM stage of CRC. In conclusion, High density of FoxP3 Tregs within tumor especially at stromal compartment leads to a favorable outcome in CRC, implicating FoxP3 Tregs are one of valuable indexes for prognostic prediction in human CRC.

摘要

叉头框蛋白P3调节性T细胞（FoxP3 Tregs）被认为是免疫逃逸和肿瘤进展的关键介质。然而，FoxP3 Tregs在人类结直肠癌（CRC）中的作用仍存在争议。在此，我们进行了一项荟萃分析，纳入了从PubMed和EBSCO中识别出的17项已发表研究中的3811例患者，以评估肿瘤浸润性FoxP3 Tregs对人类CRC预后的影响。我们发现，肿瘤内浸润到上皮内和基质中的FoxP3 Tregs与患者的1年、3年、5年和10年总生存期（OS）显著正相关，但与1年、3年、5年无病生存期（DFS）无关。有趣的是，在按肿瘤内浸润部位进行的分层分析中，浸润到基质中的FoxP3 Tregs显著改善了3年和5年OS，但仅浸润到上皮内时OS并未改善。此外，浸润到上皮内和基质中的FoxP3 Tregs与CRC的TNM分期显著负相关。总之，肿瘤内尤其是基质部位的FoxP3 Tregs高密度导致CRC预后良好，这表明FoxP3 Tregs是人类CRC预后预测的有价值指标之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/b89bec56f22d/oncotarget-08-75361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/c3a2cc03b8c0/oncotarget-08-75361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/08dcc4c71cbd/oncotarget-08-75361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/cabd9895bf32/oncotarget-08-75361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/677dfdb7a21c/oncotarget-08-75361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/d382ff52f1f3/oncotarget-08-75361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/b89bec56f22d/oncotarget-08-75361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/c3a2cc03b8c0/oncotarget-08-75361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/08dcc4c71cbd/oncotarget-08-75361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/cabd9895bf32/oncotarget-08-75361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/677dfdb7a21c/oncotarget-08-75361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/d382ff52f1f3/oncotarget-08-75361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c22/5650426/b89bec56f22d/oncotarget-08-75361-g006.jpg

相似文献

1
Tumor-infiltrating FoxP3 Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis.肿瘤浸润性FoxP3调节性T细胞预测结直肠癌患者的良好预后：一项荟萃分析。
Oncotarget. 2017 Jun 7;8(43):75361-75371. doi: 10.18632/oncotarget.17722. eCollection 2017 Sep 26.
2
The Clinicopathological and Prognostic Implications of FoxP3 Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis.FoxP3调节性T细胞在结直肠癌患者中的临床病理及预后意义：一项Meta分析
Front Physiol. 2017 Nov 21;8:950. doi: 10.3389/fphys.2017.00950. eCollection 2017.
3
High intratumoral FOXP3⁺ T regulatory cell (Tregs) density is an independent good prognosticator in nodal negative colorectal cancer.肿瘤内高丰度的FOXP3⁺调节性T细胞（Tregs）密度是淋巴结阴性结直肠癌的一个独立良好预后指标。
Int J Clin Exp Pathol. 2015 Jul 1;8(7):8227-35. eCollection 2015.
4
FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer.FOXP3+调节性T细胞：结直肠癌患者中异质性表型及对生存结果的矛盾影响
Immunol Res. 2015 Mar;61(3):338-47. doi: 10.1007/s12026-014-8616-y.
5
Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis.实体瘤中肿瘤浸润性CD57阳性淋巴细胞的预后作用：一项荟萃分析
Oncotarget. 2017 Dec 22;9(8):8111-8119. doi: 10.18632/oncotarget.23621. eCollection 2018 Jan 30.
6
The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis.结直肠癌肿瘤浸润淋巴细胞的预后价值因解剖部位不同而不同：系统评价和荟萃分析。
World J Surg Oncol. 2019 May 22;17(1):85. doi: 10.1186/s12957-019-1621-9.
7
Tumor-infiltrating CD45RO Memory T Lymphocytes Predict Favorable Clinical Outcome in Solid Tumors.肿瘤浸润性 CD45RO 记忆 T 淋巴细胞预测实体瘤的良好临床结局。
Sci Rep. 2017 Sep 4;7(1):10376. doi: 10.1038/s41598-017-11122-2.
8
Associations of different immune checkpoints-expressing CD4 Treg/ T cell subsets with disease-free survival in colorectal cancer patients.不同免疫检查点表达的 CD4+Treg/T 细胞亚群与结直肠癌患者无病生存的关系。
BMC Cancer. 2022 Jun 2;22(1):601. doi: 10.1186/s12885-022-09710-1.
9
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.肿瘤浸润性FoxP3 +调节性T细胞在癌症中的预后价值：一项系统评价和荟萃分析
Sci Rep. 2015 Oct 14;5:15179. doi: 10.1038/srep15179.
10
Foxp3 expression in CD4CD25Foxp3 regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.CD4CD25Foxp3调节性T细胞中Foxp3的表达通过抑制肿瘤免疫促进结直肠癌的发展。
J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):677-682. doi: 10.1007/s11596-016-1644-1. Epub 2016 Oct 18.

引用本文的文献

1
Chemoprevention of Colorectal Cancer-With Emphasis on Low-Dose Aspirin and Anticoagulants.结直肠癌的化学预防——重点关注低剂量阿司匹林和抗凝剂
Pharmaceuticals (Basel). 2025 May 28;18(6):811. doi: 10.3390/ph18060811.
2
The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer.结直肠癌中的肿瘤免疫微环境与T细胞相关免疫疗法
Discov Oncol. 2024 Jun 25;15(1):244. doi: 10.1007/s12672-024-01117-7.
3
Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1.调节性T细胞和自身反应性T细胞的谱系：来自老朋友人类嗜T淋巴细胞病毒1型的单细胞视角

本文引用的文献

1
Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.支柱文章：转录因子Foxp3对调节性T细胞发育的控制。《科学》2003年。299卷：1057 - 1061页。
J Immunol. 2017 Feb 1;198(3):981-985.
2
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.肿瘤浸润性FoxP3 +调节性T细胞在癌症中的预后价值：一项系统评价和荟萃分析
Sci Rep. 2015 Oct 14;5:15179. doi: 10.1038/srep15179.
3
High intratumoral FOXP3⁺ T regulatory cell (Tregs) density is an independent good prognosticator in nodal negative colorectal cancer.
Discov Immunol. 2024 May 13;3(1):kyae006. doi: 10.1093/discim/kyae006. eCollection 2024.
4
IMMUNOREACT 0: Biopsy-based immune biomarkers as predictors of response to neoadjuvant therapy for rectal cancer-A systematic review and meta-analysis.免疫反应 0：基于活检的免疫生物标志物预测直肠癌新辅助治疗的反应-系统评价和荟萃分析。
Cancer Med. 2023 Sep;12(17):17878-17890. doi: 10.1002/cam4.6423. Epub 2023 Aug 3.
5
Tumour-infiltrating lymphocytes: from prognosis to treatment selection.肿瘤浸润淋巴细胞：从预后到治疗选择。
Br J Cancer. 2023 Feb;128(3):451-458. doi: 10.1038/s41416-022-02119-4. Epub 2022 Dec 23.
6
Correlations between Circulating and Tumor-Infiltrating CD4 Treg Subsets with Immune Checkpoints in Colorectal Cancer Patients with Early and Advanced Stages.早期和晚期结直肠癌患者循环及肿瘤浸润CD4 Treg亚群与免疫检查点的相关性
Vaccines (Basel). 2022 Sep 5;10(9):1471. doi: 10.3390/vaccines10091471.
7
Molecular Basis of Extramural Vascular Invasion (EMVI) in Colorectal Carcinoma.结直肠癌的腔外血管侵犯（EMVI）的分子基础。
Ann Surg Oncol. 2022 Nov;29(12):7372-7382. doi: 10.1245/s10434-022-12212-w. Epub 2022 Aug 2.
8
Associations of different immune checkpoints-expressing CD4 Treg/ T cell subsets with disease-free survival in colorectal cancer patients.不同免疫检查点表达的 CD4+Treg/T 细胞亚群与结直肠癌患者无病生存的关系。
BMC Cancer. 2022 Jun 2;22(1):601. doi: 10.1186/s12885-022-09710-1.
9
Correlations between Circulating and Tumor-Infiltrating CD4 T Cell Subsets with Immune Checkpoints in Colorectal Cancer.结直肠癌中循环和肿瘤浸润性CD4 T细胞亚群与免疫检查点的相关性
Vaccines (Basel). 2022 Mar 30;10(4):538. doi: 10.3390/vaccines10040538.
10
Correlation and prognostic implications of intratumor and tumor draining lymph node Foxp3 T regulatory cells in colorectal cancer.结直肠癌肿瘤内及引流淋巴结 Foxp3+T 调节细胞的相关性及其预后意义。
BMC Gastroenterol. 2022 Mar 16;22(1):122. doi: 10.1186/s12876-022-02205-0.
肿瘤内高丰度的FOXP3⁺调节性T细胞（Tregs）密度是淋巴结阴性结直肠癌的一个独立良好预后指标。
Int J Clin Exp Pathol. 2015 Jul 1;8(7):8227-35. eCollection 2015.
4
The prognostic value of FOXP3+ T regulatory cells in colorectal cancer.FOXP3 + T调节性细胞在结直肠癌中的预后价值。
J BUON. 2015 Jan-Feb;20(1):114-9.
5
The effect of immune microenvironment on the progression and prognosis of colorectal cancer.免疫微环境对结直肠癌进展及预后的影响。
Med Oncol. 2014 Aug;31(8):82. doi: 10.1007/s12032-014-0082-9. Epub 2014 Jul 18.
6
Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study.HLA-I类、HLA-E、HLA-G及调节性T细胞在直肠癌中的预后价值：一项回顾性队列研究
BMC Cancer. 2014 Jul 5;14:486. doi: 10.1186/1471-2407-14-486.
7
Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival.结肠癌患者相邻正常组织中较高的FOXP3基因调控区去甲基化率与较差的生存率相关。
Mol Cancer. 2014 Jun 18;13:153. doi: 10.1186/1476-4598-13-153.
8
Prognostic value of tumor-infiltrating FoxP3+ T cells in gastrointestinal cancers: a meta analysis.胃肠道癌症中肿瘤浸润性FoxP3 + T细胞的预后价值：一项荟萃分析
PLoS One. 2014 May 14;9(5):e94376. doi: 10.1371/journal.pone.0094376. eCollection 2014.
9
The intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic clues.结直肠癌肿瘤内亚部位与 CD8(+)和 FOXP3(+)T 淋巴细胞的关系提供了重要的预后线索。
Br J Cancer. 2014 May 13;110(10):2551-9. doi: 10.1038/bjc.2014.161. Epub 2014 Mar 27.
10
CD8+ and FOXP3+ tumor-infiltrating T cells before and after chemoradiotherapy for rectal cancer.直肠癌放化疗前后CD8 +和FOXP3 +肿瘤浸润性T细胞
Ann Surg Oncol. 2014 Jun;21 Suppl 3:S414-21. doi: 10.1245/s10434-014-3584-y. Epub 2014 Feb 25.