University of Würzburg, Biocenter, Department of Microbiology, Am Hubland, D-97074, Wuerzburg,Germany.
University of Würzburg, Biocenter, Department of Microbiology, Am Hubland, D-97074, Wuerzburg,Germany.
Int J Med Microbiol. 2018 Jan;308(1):155-160. doi: 10.1016/j.ijmm.2017.10.008. Epub 2017 Oct 28.
Simkania negevensis is an obligate intracellular Chlamydia-like pathogen of the respiratory tract. It infects and multiplies in a wide range of hosts, from unicellular amoeba to a variety of human cells, such as epithelial HeLa and macrophage-like THP1 cells. The Simkania-containing vacuole (SnCV) forms close contacts with the endoplasmic reticulum (ER), and recruits and affects mitochondria of the host cells. Simkania prevent ER stress and require the components of the retrograde transport, as well as several mitochondrial and peroxisomal proteins, for proper development. This review recapitulates our current knowledge about the involvement of various cellular organelles in the life cycle of S. negevensis.
纤环支原体是一种必需的呼吸道细胞内衣原体样病原体。它可以在从单细胞变形虫到各种人类细胞（如上皮细胞 HeLa 和巨噬细胞样 THP1 细胞）的广泛宿主中感染和繁殖。含有纤环支原体的空泡（SnCV）与内质网（ER）形成紧密接触，并招募和影响宿主细胞的线粒体。纤环支原体防止内质网应激，并需要逆行运输的成分，以及几种线粒体和过氧化物酶体蛋白，以实现正常发育。这篇综述总结了我们目前对各种细胞细胞器在纤环支原体生命周期中的作用的认识。
