Bindu T S, Vyas Sameer, Khandelwal Niranjan, Bhatia Vikas, Dhandapani Sivashanmugam, Kumar Ajay, Ahuja Chirag K
Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Radiol Imaging. 2017 Jul-Sep;27(3):268-273. doi: 10.4103/ijri.IJRI_454_16.
To evaluate utility, pattern, and extent of perfusion abnormalities in traumatic brain injury by using whole-brain computed tomography perfusion (CTP) and to assess co-relation of CTP data clinically with Glasgow outcome score (GOS).
Prospective analytic evaluation of the traumatic head injury patients who were immediately taken up for CTP was done. Patient's demographic, clinical, and radiological findings were tabulated and analyzed. GOS was measured by a neurosurgeon after 3 months of trauma who was blinded to CTP results.
Of the 78 patients included in this study, 28 patients were found to have GOS 5, 19 of them had GOS 4, 27 of them had GOS 3, and 4 of them had a GOS 2. Higher mean cerebral blood flow (CBF) and cerebral blood volume (CBV) values were observed in those who had a better GOS, i.e., 4 or 5, whereas those in the GOS range ≤3 had lower mean CBF and CBV values.
Statistically significant positive correlation was found between cerebral perfusion parameters with that of GOS. CBF of frontal area shows better correlation with GOS. CBF was the most important predictor among all the perfusion parameters.
通过全脑计算机断层扫描灌注成像（CTP）评估创伤性脑损伤中灌注异常的实用性、模式和范围，并评估CTP数据与格拉斯哥预后评分（GOS）的临床相关性。
对立即接受CTP检查的创伤性颅脑损伤患者进行前瞻性分析评估。将患者的人口统计学、临床和影像学检查结果列表并进行分析。创伤3个月后由一名对CTP结果不知情的神经外科医生测量GOS。
本研究纳入的78例患者中，28例GOS为5分，19例为4分，27例为3分，4例为2分。GOS较好（即4或5分）的患者平均脑血流量（CBF）和脑血容量（CBV）值较高，而GOS≤3分的患者平均CBF和CBV值较低。
脑灌注参数与GOS之间存在统计学上显著的正相关。额叶区域的CBF与GOS的相关性更好。在所有灌注参数中，CBF是最重要的预测指标。
