Kostka Joanna, Sikora Joanna, Kostka Tomasz
Department of Geriatrics, Healthy Ageing Research Centre.
Department of Physical Medicine.
Clin Interv Aging. 2017 Oct 19;12:1753-1760. doi: 10.2147/CIA.S146494. eCollection 2017.
The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women.
Ninety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (P) and optimal shortening velocity (υ) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured.
Women taking ACEI were on average almost 2 years older than the women who did not take ACEI. They took more medicines and were also characterized by significantly lower level of ACE, but they did not differ in terms of PA level, results of functional performance and parameters characterizing muscle functions. No correlations of ACE activity with P and handgrip strength, as well as with PA or functional performance were found. Higher ACE activity was connected with lower υ for women who did not take any ASBMs (rho =-0.37; =0.01).
Serum ACE activity was not associated with muscle strength, power and functional performance in both ASBM users and nonusers, but was associated with optimal shortening velocity of quadriceps muscles in older women. Further prospective studies are needed to assess if ACEIs or other ASBMs may slow down the decline in muscle function and performance.
本研究的目的是评估血管紧张素转换酶（ACE）活性是否与肌肉功能（力量、功率和速度）相关，以及评估ACE抑制剂（ACEIs）和其他血管紧张素系统阻断药物（ASBMs）是否会影响老年女性的肌肉性能。
95名居住在社区的老年女性参与了本研究。测量了人体测量数据、血液ACE活性分析、膝伸肌的最大功率（P）和最佳缩短速度（υ）、握力、身体活动（PA）和功能表现。
服用ACEI的女性平均比未服用ACEI的女性大近2岁。她们服用的药物更多，ACE水平也显著较低，但在PA水平、功能表现结果和肌肉功能特征参数方面没有差异。未发现ACE活性与P、握力以及PA或功能表现之间存在相关性。对于未服用任何ASBMs的女性，较高的ACE活性与较低的υ相关（rho = -0.37；P = 0.01）。
在使用和未使用ASBMs的人群中，血清ACE活性均与肌肉力量、功率和功能表现无关，但与老年女性股四头肌的最佳缩短速度有关。需要进一步的前瞻性研究来评估ACEIs或其他ASBMs是否可能减缓肌肉功能和性能的下降。
